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外泌體的應(yīng)用——有機(jī)遇,也有挑戰(zhàn)
外泌體(exosome)是細(xì)胞分泌囊泡(extracellular vesicles)的一種亞型,存在于生物體液中,并參與多種生理和病理過(guò)程。外泌體被認(rèn)為是細(xì)胞間通信的一種新機(jī)制,允許細(xì)胞交換蛋白質(zhì)、脂質(zhì)和遺傳物質(zhì)。過(guò)去,細(xì)胞分泌的外泌體一度被認(rèn)為只是參與廢物排泄;現(xiàn)在,隨著高通量蛋白質(zhì)組學(xué)和基因組學(xué)的發(fā)展,外泌體被廣泛認(rèn)為是生物體內(nèi)細(xì)胞間短距離和長(zhǎng)距離交流的高度保守的途徑,這種細(xì)胞間通信對(duì)于正常細(xì)胞和腫瘤細(xì)胞都是非常重要的。[查看]
http://m.baichuan365.com/Article/wmtdyyyjyyytz_1.html
人腦視覺(jué)信息編解碼研究方面取得新進(jìn)展
現(xiàn)代認(rèn)知神經(jīng)科學(xué)以及功能磁共振成像技術(shù)(functional Magnetic Resonance Imaging, fMRI)的不斷發(fā)展使得采用科學(xué)手段對(duì)大腦視覺(jué)皮層信號(hào)進(jìn)行解讀成為可能。研究人腦視覺(jué)信息解碼模型不僅可以加深人們對(duì)人腦視覺(jué)信息處理機(jī)制的研究,還可以有力地促進(jìn)新一代腦-機(jī)接口(Brain-Computer Interface, BCI)技術(shù)的發(fā)展。[查看]
http://m.baichuan365.com/Article/rnsjxxbjmyjfmqdxjz_1.html
細(xì)胞乙酰化的輻射增敏研究取得進(jìn)展
組蛋白乙酰化是表觀遺傳修飾的重要方式之一。腫瘤的產(chǎn)生與組蛋白乙酰化與去乙酰化的調(diào)控失衡關(guān)系密切,而組蛋白去乙酰化酶抑制劑(histone deacetylase inhibit,HDACi)可以改變乙酰化調(diào)控的失衡狀態(tài),提高細(xì)胞乙酰化水平,抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移。目前,研究人員紛紛嘗試將HDACi用于輻射增敏研究,普遍認(rèn)為經(jīng)HDACi預(yù)處理的細(xì)胞乙酰化水平越高,輻射敏感性越強(qiáng),但目前該研究?jī)H限于不同劑量HDACi對(duì)細(xì)胞輻射敏感性的影響,對(duì)HDACi預(yù)處理時(shí)間的影響尚未見(jiàn)報(bào)道。[查看]
http://m.baichuan365.com/Article/xbyxhdfszmyjqdjz_1.html
禮來(lái)GLP-1受體激動(dòng)劑Trulicity大規(guī)模長(zhǎng)期心血管預(yù)后研究顯著降低M<font color='red'>ACE</font>事件風(fēng)險(xiǎn)
REWIND研究是一項(xiàng)多中心、隨機(jī)、雙盲、安慰劑對(duì)照研究,旨在評(píng)估每周一次胰高血糖素樣肽1受體激動(dòng)劑(GLP-1RA)Trulicity 1.5mg相對(duì)于安慰劑(均添加至標(biāo)準(zhǔn)護(hù)理)對(duì)2型糖尿病成人患者心血管(CV)事件的作用。主要CV終點(diǎn)為主要不良心血管事件(MACE,包括心血管死亡、非致死性心肌梗死、非致死性卒中)的首次發(fā)生時(shí)間,次要終點(diǎn)包括主要CV終點(diǎn)中每個(gè)組成部分,以及包括視網(wǎng)膜或腎臟疾病在內(nèi)的復(fù)合臨床微血管預(yù)后、不穩(wěn)定性心絞痛住院、需要住院治療的心衰、需要就診的緊急心衰、全因死亡率。[查看]
http://m.baichuan365.com/Article/llglp1stjdjtrulicity_1.html
10月29世界中風(fēng)日,史賽克提醒公眾發(fā)現(xiàn)中風(fēng)征象采取FAST法應(yīng)對(duì)
通過(guò) FAST 法識(shí)別腦中風(fēng)中風(fēng)發(fā)作前,會(huì)有一些常見(jiàn)的征象,即“FAST”,即臉部 (Face)、手臂 (Arms)、言語(yǔ) (Speech)、時(shí)間 (Time) 四個(gè)單詞英文首字母的縮寫(xiě)。臉部 (Face) 指面龐向一側(cè)下垂,或浮現(xiàn)扭曲的笑容。手臂 (Arms) 指患者可能無(wú)法將雙臂舉到同一高度。言語(yǔ) (Speech) 指觀察患者是否口齒清晰、言辭達(dá)意或能聽(tīng)懂對(duì)方說(shuō)的話(huà)。最后一個(gè)要素是時(shí)間 (Time);如果患者出現(xiàn)以上任何癥狀,應(yīng)立即撥打急救電話(huà)。[查看]
http://m.baichuan365.com/Article/10y29sjzfrssktxgzfxz_1.html
突破!新技術(shù)或能成功追蹤胚胎祖細(xì)胞發(fā)育至多細(xì)胞有機(jī)體的整個(gè)過(guò)程
胚胎發(fā)育是高度復(fù)雜的有機(jī)體發(fā)育的一個(gè)重要階段,比如人類(lèi),僅有非常有限的胚胎祖細(xì)胞能夠成功制造出成年機(jī)體內(nèi)部所有類(lèi)型的細(xì)胞,為了理解這一過(guò)程發(fā)生的機(jī)制,研究人員就需要新方法能夠測(cè)定克隆歷史的發(fā)生,同時(shí)還能在單細(xì)胞分辨率下進(jìn)行細(xì)胞的識(shí)別;基于此,研究人員開(kāi)發(fā)出了一種名為ScarTrace的新技術(shù),該技術(shù)能夠添加熒光蛋白轉(zhuǎn)基因的串聯(lián)拷貝,從而就能在CRISPR-Cas9基因編輯的轉(zhuǎn)錄過(guò)程中有效識(shí)別所遺留的“疤痕”。[查看]
http://m.baichuan365.com/Article/tpxjshncgzzptzxbfyzd_1.html
免疫療法可幾乎完全消除異體移植排異反應(yīng)
根據(jù)最近在美國(guó)血液協(xié)會(huì)年度會(huì)議上由來(lái)自西雅圖兒童研究所做出的報(bào)告,一項(xiàng)臨床II期試驗(yàn)結(jié)果表明Abatacept能夠幾乎完全治愈晚期癌癥患者或血液紊亂患者在接受干細(xì)胞移植手術(shù)后出現(xiàn)的致命性的排異反應(yīng)(graft-versus-host disease,GvHD)。[查看]
http://m.baichuan365.com/Article/mylfkjhwqxcytyzpyfy_1.html
SCTM:發(fā)現(xiàn)一種新的干細(xì)胞來(lái)源---骨膜組織
在一項(xiàng)新的研究中,研究人員發(fā)現(xiàn)在常規(guī)的髖關(guān)節(jié)置換術(shù)(hip replacement surgery)期間通常丟棄的骨膜組織富含成體干細(xì)胞,有望提供一種用于再生醫(yī)學(xué)的干細(xì)胞新來(lái)源。相關(guān)研究結(jié)果近期發(fā)表在Stem Cells Translational Medicine期刊上[查看]
http://m.baichuan365.com/Article/sctmfxyzxdgxblygmzz_1.html
ACS Nano:突破!科學(xué)家利用來(lái)自尿液的生物標(biāo)志物進(jìn)行早期癌癥篩查
日前,來(lái)自韓國(guó)蔚山國(guó)家科學(xué)技術(shù)研究所的研究人員通過(guò)研究開(kāi)發(fā)出了一種新技術(shù),該技術(shù)能夠有效在尿液或血液中有效鑒別出促進(jìn)癌癥發(fā)生的物質(zhì),相關(guān)研究刊登于國(guó)際雜志ACS Nano上。文章中,研究人員開(kāi)發(fā)出了一種集成的離心微流體平臺(tái)(Exodisc),這種設(shè)備能夠?qū)δ蛞褐械陌饽づ?extracellular vesicles,EVs)進(jìn)行分離。[查看]
http://m.baichuan365.com/Article/acsnanotpkxjlylznyds_1.html
重磅!科學(xué)家深入解析CRISPR起源的5個(gè)謎團(tuán)
如今研究者以CRISPR來(lái)對(duì)成簇規(guī)律間隔的短回文重復(fù)序列(clustered regularly interspaced short palindromic repeats)進(jìn)行命名,同時(shí)他們還發(fā)現(xiàn),CRISPR-Cas能夠幫助細(xì)菌抵御外來(lái)病毒的入侵,盡管CRISPR系統(tǒng)能夠用來(lái)進(jìn)行基因的編輯,但Mojica和其它研究者們關(guān)于該系統(tǒng)的工作機(jī)制仍然存在一些問(wèn)題,這種微生物免疫系統(tǒng)是如何進(jìn)化的?[查看]
http://m.baichuan365.com/Article/zbkxjsrjxcrisprqyd5g_1.html
只有在掃描隧道顯微鏡下才看得的世界最小耐力賽
迄今為止第一個(gè)納米賽車(chē)比賽,nanorace。有一個(gè)很?chē)?yán)肅的科學(xué)目的:對(duì)一臺(tái)最近安裝的特殊掃描隧道顯微鏡進(jìn)行測(cè)試。這次比賽也同時(shí)能讓人們深入了解納米汽車(chē)如何應(yīng)對(duì)極端的環(huán)境。[查看]
http://m.baichuan365.com/Article/zyzsmsdxwjxckddsjzxn_1.html
Grace Syloid(R)【FP多功能介孔硅膠】在藥用輔料中的應(yīng)用
Syloid(R) FP硅膠為美國(guó)Grace推出的一系列多功能介孔微粉硅膠,其獨(dú)特的內(nèi)部三維結(jié)構(gòu)、吸收容量及顆粒尺寸等特性,使其可以在藥品、營(yíng)養(yǎng)品和保健品等應(yīng)用具有顯著優(yōu)勢(shì)。在藥用輔料領(lǐng)域,具有助流劑、消除靜電、抗結(jié)塊、防潮保護(hù)、改善穩(wěn)定性等功能,備受知名醫(yī)藥企業(yè)青睞。[查看]
http://m.baichuan365.com/Article/gracesyloidfpdgnjkgj_1.html
安慰劑為何有效?這要問(wèn)免疫系統(tǒng)
安慰劑效應(yīng)(Placebo Effect)這個(gè)現(xiàn)象由來(lái)已久。科學(xué)家們發(fā)現(xiàn)在許多場(chǎng)合下,安慰劑也能給患者的健康帶來(lái)益處:一些研究發(fā)現(xiàn)安慰劑能緩解偏頭痛患者的疼痛與其他癥狀;另一些科研人員則發(fā)現(xiàn)在用安慰劑替代藥物后,帕金森患者的癥狀沒(méi)有出現(xiàn)反彈。[查看]
http://m.baichuan365.com/Article/awjwhyxzywmyxt_1.html
【FAPGG】,血管緊張素轉(zhuǎn)換酶檢測(cè)用底物
西寶生物提供高品質(zhì)N-[3-(2-呋喃基)丙烯酰]-L-苯丙氨酰-甘氨酰-甘氨酸(FAPGG)。血管緊張素轉(zhuǎn)換酶(ACE)是腎素-血管緊張素-醛固酮的重要成分,主要用于肺部病的診斷,F(xiàn)APGG作為ACE底物用于測(cè)定其酶活性。[查看]
http://m.baichuan365.com/Article/fapggxgjzszhmjcydw_1.html
Grace 923級(jí)硅膠 - GB/T11132及ASTM D1319專(zhuān)業(yè)推薦
923級(jí)硅膠是GB/T11132和ASTM D1319標(biāo)準(zhǔn)推薦使用的、專(zhuān)門(mén)用于分析石油中烴類(lèi)含量的高純度色譜專(zhuān)用硅膠。美國(guó)Grace 公司在硅膠材料領(lǐng)域久負(fù)盛名,西寶生物專(zhuān)業(yè)代理Grace生產(chǎn)的923級(jí)硅膠,免費(fèi)熱線(xiàn)400 021 8158。[查看]
http://m.baichuan365.com/Article/xbswzytggrace923jgjg_1.html
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Crystal Violet Indicator, 0.1% (w/v) in Glacial Acetic Acid, for Nonaqueous Titrations
Crystal Violet Indicator, 0.1% (w/v) in Glacial Acetic Acid, for Nonaqueous Titrations
Crystal Violet Indicator, 0.2% (w/v) in Glacial Acetic Acid, for Nonaqueous Titrations
Crystal Violet Indicator, 0.2% (w/v) in Glacial Acetic Acid, for Nonaqueous Titrations
Crystal Violet Solution 1% in Glacial Acetic Acid
Crystal Violet Solution 1% in Glacial Acetic Acid
Non-aqueous filling solution; 1mol/litre lithium chloride (LiCl), dissolv in acetic acid
Non-aqueous filling solution; 1mol/litre lithium chloride (LiCl), dissolv in acetic acid
Saturated Sodium Perchlorate in Glacial Acetic Acid
Saturated Sodium Perchlorate in Glacial Acetic Acid
Acetic Acid
Acetic Acid
1w/v% Crystal Violet Acetic Acid Solution
1w/v% Crystal Violet Acetic Acid Solution
0.2w/v% p- Naphtholbenzein Acetic Acid Solution
0.2w/v% p- Naphtholbenzein Acetic Acid Solution
0.1N sodium acetate in glacial acetic acid
0.1N sodium acetate in glacial acetic acid
TBN Titration solvent-2:1 chlorobenzene and glacial acetic acid
TBN Titration solvent-2:1 chlorobenzene and glacial acetic acid
(S)-(-)-2-Methoxy-2-(trifiuoromethyl)phenylacetic Acid
(S)-(-)-2-Methoxy-2-(trifiuoromethyl)phenylacetic Acid
(R)-(+)-2-Methoxy-2-(trifluoromethyl)phenylacetic Acid
(R)-(+)-2-Methoxy-2-(trifluoromethyl)phenylacetic Acid
Chromium(lll) Acetylacetonate
Chromium(lll) Acetylacetonate
4-Acetamido-TEMPO, free radical
4-Acetamido-TEMPO, free radical
4-Acetamido-TEMPO, free radical
4-Acetamido-TEMPO, free radical
Butyl Acetate
Butyl Acetate
Germanium H2O / Trace HF 1,000ug/mL
Germanium H2O / Trace HF 1,000ug/mL
Germanium H2O /Trace HF 1,000ug/mL
Germanium H2O /Trace HF 1,000ug/mL
Germanium H2O / Trace HF 1,000ug/mL
Germanium H2O / Trace HF 1,000ug/mL
Germanium H2O / Trace HF 10,000ug/mL
Germanium H2O / Trace HF 10,000ug/mL
Acetic Acid
Acetic Acid
Acetic Acid
Acetic Acid
Acetonitrile
Acetonitrile
Ethyl Acetate
Ethyl Acetate
Acetone, Spectrosol(R)
Acetone, Spectrosol(R)
Acetonitrile, Spectrosol(R)
Acetonitrile, Spectrosol(R)
Acetonitrile
Acetonitrile
Ethyl Acetate
Ethyl Acetate
Acetonitrile, Luminasol(R)
Acetonitrile, Luminasol(R)
Acetanilide Standard
Acetanilide Standard
Acetate in water 1000ppm
Acetate in water 1000ppm
Acetate 1mg/ml (1,000ppm)
Acetate 1mg/ml (1,000ppm)
Acetate- 0.2mg/ml (200ppm)
Acetate- 0.2mg/ml (200ppm)
Acetate 100ppm in H2O
Acetate 100ppm in H2O
Acetaldehyde
Acetaldehyde
Trace Elements in White Rice Flour Set(Cd Level I&II)
Trace Elements in White Rice Flour Set(Cd Level I&II)
Trace Elements in Tea Leaf Powder
Trace Elements in Tea Leaf Powder
Trace Elements, Arsenobetaine anc jrcury in Swordfish Tissue
Trace Elements, Arsenobetaine anc jrcury in Swordfish Tissue
Trace Elements and Arsenic Compounds in Seaweed (Hijiki)
Trace Elements and Arsenic Compounds in Seaweed (Hijiki)
Trace Elements, Arsenobetaine and Methylmercury in Cod Fish Tissue
Trace Elements, Arsenobetaine and Methylmercury in Cod Fish Tissue
Trace Elements in Lake Sediment
Trace Elements in Lake Sediment
Trace Elements in River Water (Elevated Level)
Trace Elements in River Water (Elevated Level)
Trace Elements in Marine Sediment
Trace Elements in Marine Sediment
Melting Point Standard Set Vanillin (81-83°C) Phenacetin (134-136°C)°Caffeine (235-237°C)
Melting Point Standard Set Vanillin (81-83°C) Phenacetin (134-136°C)°Caffeine (235-237°C)
Tributyltin(IV) Acetate
Tributyltin(IV) Acetate
N, N-Dimethylaceatamide
N, N-Dimethylaceatamide
N, N-Dimethylaceatamide
N, N-Dimethylaceatamide
Acetic Acid, CH3COOH, 20% v/v
Acetic Acid, CH3COOH, 20% v/v
Mobile Phase Buffer pH 4.5 - Sodium Acetate Trihydrate
Mobile Phase Buffer pH 4.5 - Sodium Acetate Trihydrate
Mobile Phase Buffer pH 4.5 - Sodium Acetate Trihydrate
Mobile Phase Buffer pH 4.5 - Sodium Acetate Trihydrate
Zinc Acetate 10% w/v
Zinc Acetate 10% w/v
Sodium Acetate, 0.2M
Sodium Acetate, 0.2M
Sodium Acetate, 2M
Sodium Acetate, 2M
Acetonitrile, 50% v/v
Acetonitrile, 50% v/v
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
APDC Butyl Acetate-Ethanol Reagent
APDC Butyl Acetate-Ethanol Reagent
N-Acetyl-L-Cysteine,crystallizate
N-Acetyl-L-Cysteine,crystallizate
N-Acetylneuraminic acid aldolase
N-Acetylneuraminic acid aldolase
N-Acetylneuraminic acid aldolase
N-Acetylneuraminic acid aldolase
Oxaloacetate Decarboxylase
Oxaloacetate Decarboxylase
Acetate-CoA Ligase (Acetyl-CoA Synthetase),from yeast, lyophilizate
Acetate-CoA Ligase (Acetyl-CoA Synthetase),from yeast, lyophilizate
Acetate-CoA Ligase (Acetyl-CoA Synthetase),from microorganism, lyophilizate
Acetate-CoA Ligase (Acetyl-CoA Synthetase),from microorganism, lyophilizate
Cholesterol Esterase, from Candida cylindracea, lyophilizate
Cholesterol Esterase, from Candida cylindracea, lyophilizate
Cholesterol Esterase, from Candida cylindracea, solution
Cholesterol Esterase, from Candida cylindracea, solution
CMP-N-Acetylneuraminic Acid,sodium salt
CMP-N-Acetylneuraminic Acid,sodium salt
UDP-N-Acetylglucosamine,disodium salt
UDP-N-Acetylglucosamine,disodium salt
Ethyclozate metabolite (CIA:5-Chloro-3 (1H)-indazolacetate)
Ethyclozate metabolite (CIA:5-Chloro-3 (1H)-indazolacetate)
ACE5599
ACE5599
N-Chloroacetyl-2,6-diethylaniline
N-Chloroacetyl-2,6-diethylaniline
Ethylene glycol bis (trichloroacetate)
Ethylene glycol bis (trichloroacetate)
Presep(R) Diatomaceous Earth, Granular (Column Volume 15mL)
Presep(R) Diatomaceous Earth, Granular (Column Volume 15mL)
Presep(R) Diatomaceous Earth, Granular (Column Volume 6ml)
Presep(R) Diatomaceous Earth, Granular (Column Volume 6ml)
USP Solution Acetate Buffer TS Conforms to USP 34
USP Solution Acetate Buffer TS Conforms to USP 34
USP Solution Acetate Buffer TS Conforms to USP 34
USP Solution Acetate Buffer TS Conforms to USP 34
USP Solution Acetic Acid 2.00 Normal Conforms to USP 34
USP Solution Acetic Acid 2.00 Normal Conforms to USP 34
USP Solution Acetic Acid 2.00 Normal Conforms to USP 34
USP Solution Acetic Acid 2.00 Normal Conforms to USP 34
USP Solution Acetic Acid-Ammonium Acetate Buffer TS Conforms to USP 34
USP Solution Acetic Acid-Ammonium Acetate Buffer TS Conforms to USP 34
USP Solution Acetic Acid-Ammonium Acetate Buffer TS Conforms to USP 34
USP Solution Acetic Acid-Ammonium Acetate Buffer TS Conforms to USP 34
USP Solution Cupric Acetate TS Conforms to USP 34
USP Solution Cupric Acetate TS Conforms to USP 34
USP Solution Cupric Acetate TS Conforms to USP 34
USP Solution Cupric Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Potassium Acetate TS Conforms to USP 34
USP Solution Potassium Acetate TS Conforms to USP 34
USP Solution Potassium Acetate TS Conforms to USP 34
USP Solution Potassium Acetate TS Conforms to USP 34
USP Solution Sodium Acetate TS Conforms to USP 34
USP Solution Sodium Acetate TS Conforms to USP 34
USP Solution Sodium Acetate TS Conforms to USP 34
USP Solution Sodium Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Acetic acid (30%)
European Pharmacopoeia Reagent Acetic acid (30%)
European Pharmacopoeia Reagent Acetic acid, Dilute (12%)
European Pharmacopoeia Reagent Acetic acid, Dilute (12%)
European Pharmacopoeia Reagent Acetic anhydride Solution R1
European Pharmacopoeia Reagent Acetic anhydride Solution R1
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Methoxyphenylacetic reagent
European Pharmacopoeia Reagent Methoxyphenylacetic reagent
European Pharmacopoeia Reagent Thioacetamide Solution
European Pharmacopoeia Reagent Thioacetamide Solution
European Pharmacopoeia Reagent Zinc acetate Solution
European Pharmacopoeia Reagent Zinc acetate Solution
European Pharmacopoeia Reagent Buffered acetone Solution
European Pharmacopoeia Reagent Buffered acetone Solution
European Pharmacopoeia Reagent Acetate Buffer Solution PH4.6
European Pharmacopoeia Reagent Acetate Buffer Solution PH4.6
6-Acetylcodeine,1.0mg/mL 于乙腈
6-Acetylcodeine,1.0mg/mL 于乙腈
Acesulfame potassium impurity B
Acesulfame potassium impurity B
Trace Elements in Water 標(biāo)準(zhǔn)物質(zhì)
Trace Elements in Water 標(biāo)準(zhǔn)物質(zhì)
Androsterone 3-acetate,certified
Androsterone 3-acetate,certified
Corticosterone-21-acetate
Corticosterone-21-acetate