Custom Synthesis of modified PEGs

來源：seebio.cn作者：西寶生物人氣：-發(fā)表時間：2012-04-01 10:15:06【大中小】

Seebio Biotech, Inc. provides a variety of modified PEGs, for example, single functional group PEGs (mPEG), symmetry double functional group PEGs, asymmetric double functional group PEGs, multi-arm PEGs, PEG hybrid system and other derivatives.

mPEG、mPEG-NH2、mPEG-SS、mPEG-SC、mPEG2-NHS、mPEG-SPA、mPEG-ALD、mPEG-MAL、HO-PEG-COOH、mPEG-b-PS、mPEG-b-PI、mPEG-b-PAN、mPEG-b-PCL、mPEG-b-PMMA、α-hydroxyl-PEG-ω- amide、 mPEG-carboxyl、mPEG- cyan、hyperbranched polyglycerol , etc.

Functional groups include:
Maleimide(MAL),
NHS este(succinimidyl, SCM, SC, SG-glutarate, SS-succinate),
ortho-Pyridyldisulfide(OPSS),
n-Succinimidyl-3-(2-pyridyldithiol)propionate (SPDP),

Fluorescein (FITC),
Biotin,
Silane,
Nitrophenyl carbonate(NPC),
Amine (NH2, Boc or Fmoc),
Acid (COOH),
Lipid (DSPE),
Aldehyde,
Isocyanate (NCO),
Isothiocyanate (NCS),
Vinylsulfone (VS),
Hydrazide,
Acrylate (acryloyl),
Epoxide,
Succinic and Glutaric acid,
Tosylate and Mesylate

Features & Tech Advantages

1. Multiple functional group modified service with a good property and high purity, Mw: 500-80,000, Disperse(PDI) <1.05 (PDI of general market product: 1.60);
2. Simplified manufacture process, low impurity, stable quality;
3. Batch production, cost under control;
4. More than 800 different grades available;
5. Specific grade synthesis acceptable.

1、Single Functional Group PEGs (mPEG-R)

R:	-CH₂NH₂；-COOH；-CH₂CH₂COOH；-EPMAL；-SC；Biotin
	-PPMAL；-SPA；-OCOOPhNO₂；-CHO；-VS；-S-S-Pyridine；-Thiol
	-CH(OEt)₂；-SH；-SS；-SG；-SCM；-OTS；-ButyrALD； -ALD；-AC； -Alkyne；-Azide； -Epoxide；-Hydrazide；-NCO；-NPC；-OPSS；SG；-Silane；-VS

2、Asymmetric Double Functional Group PEGs (R₁-PEG-R₂)

R1:	H-；NH₂-；COOH-；MAL-；ACLT-；Biotin-；Gluc-；Gala-；AC-；BOC-；NH-；DSPE-；Fluorescein-；OPSS-；Thiol-；ACRL-；FMOC-NH-；
R2:	-NH₂；-CH₂NH₂；-CH₂CH₂CH₂NH₂；-COOH；-CH₂CH₂COOH；-CHO；-CH(OEt)₂_；-NHS；-MAL；SCM；-SC；-Biotin；-Acid；-CM；-SVA；-VA；-Silane；

3、Symmetry Double Functional Group PEGs (R-PEG-R)

R:	NH₂；CH₂NH₂；CH₂CH₂COOH；EP-MAL；PP-MAL；NHS；OPSS；AC；ALD；Azide；；EP；GA；Hydrazide；NPC；SH；ACRL；-ButyrALD；-Thiol； Tosylate；VA；

4、Multi-arm Branched PEGs (PEG_n-R(n=2、3、4))

R:	-TS；-NP；-GS2；-MAL（C2、C5）；-ALD；-PA；CA；-COO-NHS;-CH₂CH₂CH₂-NHCO-(CH₂)₃-COO-NHS

5、Lysine Branched PEGs

X:	-O-NHS; -NH-CH₂CH₂-CHO; -NH(CH₂)₂-NHCO-(CH₂)-maleimide

6、Forked PEGs

X:	-CH₂CH₂-NHCO-(CH₂)₃-COO-NHS; -CH₂ CH₂NH₂;--CH₂CH₂-NHCO-(CH₂)_2-maleimide

7、Released PEGs (mPEG-(CH₂)n-Y-linker-X)

X:	-TS；
Y:	-COO-C₆H₅-;-COO-C₆H₃(CH₃)₂

8、Multi-arm PEGs (PEG-X)_n（n=3、4、6、8）

X:	-CO-CH₂CH₂-COO-NHS; -CO-CH₂CH₂CH₂-COO-NHS; -CH₂CH₂CH₂CH₂-COO-NHS; -CH₂CH₂CH₂NH₂; -CH₂CH₂NH₂; -CH₂CH₂SH; -(CH₂)₃-NHCO-CH₂CH₂-Maleimide; -COO-phenyl-NO₂

9、Copolymers

A-b-PEG	A：PS；PI；PAN；PCL；PMMA；PPO；PGLY；PECH
mPEG-b-A	A：PS；PI；PAN；PCL；PMMA；PPO；PGLY；PECH
A-b-PEG-b-A	A：PHB； PHB/V；PCL；PLA
R1-(PEG-b-A)-R2	A：PS；PI；PAN；PCL；PMMA；PPO；PGLY；PECH R1：Br；R2：OH
R1-(A-b-PEG)-R2	A：PHB；PHB/V；PCL；PLA；PPO；PGLY；PECH R1：Br；R2：OH
R-(PEG-b-A-b-PEG)-R	A：PPO；PGLY；PECH R：OH
(PEG-b-A)-R	A：PS；PI R：OH
R-(PEG-b-A-b-PEG)	A：PS；PI R：OH
A-b-(PEG)2	A：PS；PI

Related Products :

Product Code	Mw	Replacement	Dispersibility
mPEG-R
mPEG-OH-3.4K*	3400±340		≤1.05
mPEG-OH-10K	10000±1000		≤1.06
mPEG-OH-20K	20000±2000		≤1.06
mPEG-OH-30K	30000±3000		≤1.08
mPEG-OH-40K*	40000±4000		≤1.08
mPEG-NH₂-2K	2000±200	≥95%	≤1.05
mPEG-NH₂-3.4K*	3400±340	≥95%	≤1.05
mPEG-NH₂-5K	5000±500	≥95%	≤1.05
mPEG-NH₂-10K	10000±1000	≥95%	≤1.06
mPEG-NH₂-20K	20000±2000	≥90%	≤1.08
mPEG-NH₂-30K	30000±3000	≥90%	≤1.08
mPEG-NH₂-40K*	40000±4000	≥90%	≤1.08
mPEG-SC-2K	2000±200	≥95%	≤1.05
mPEG-SC-3.4K*	3400±340	≥95%	≤1.05
mPEG-SC-5K	5000±500	≥95%	≤1.05
mPEG-SC-10K	10000±1000	≥95%	≤1.06
mPEG-SC-20K	20000±2000	≥90%	≤1.08
mPEG-SC-30K	30000±3000	≥90%	≤1.08
mPEG-SC-40K*	40000±4000	≥90%	≤1.08
mPEG-MAL-20K	20000±2000	≥90%	≤1.08
mPEG-MAL-30K	30000±3000	≥90%	≤1.08
mPEG-MAL-40K*	40000±4000	≥90%	≤1.08
mPEG--COOH-2K	2000±200	≥95%	≤1.05
mPEG-COOH-3.4K*	3400±340	≥95%	≤1.05
mPEG-COOH-5K	5000±500	≥95%	≤1.05
mPEG-COOH-10K	10000±1000	≥95%	≤1.06
mPEG-COOH-20K	20000±2000	≥90%	≤1.08
mPEG-COOH-30K	30000±3000	≥90%	≤1.08
mPEG-COOH-40K*	40000±4000	≥90%	≤1.08
mPEG-SPA-2K	2000±200	≥95%	≤1.05
mPEG-SPA-3.4K*	3400±340	≥95%	≤1.05
mPEG-SPA-5K	5000±500	≥95%	≤1.05
mPEG-NHS-10K	10000±1000	≥90%	≤1.06
mPEG-NHS-20K	20000±2000	≥90%	≤1.08
mPEG-NHS-30K	30000±3000	≥90%	≤1.08
mPEG-NHS-40K*	40000±4000	≥90%	≤1.08
mPEG-AC-2K	2000±200	≥95%	≤1.05
mPEG-AC-3.4K*	3400±340	≥95%	≤1.05
mPEG-AC-5K	5000±500	≥95%	≤1.05
mPEG-AC-10K	10000±1000	≥90%	≤1.06
mPEG-AC-20K	20000±2000	≥90%	≤1.08
mPEG-AC-30K	30000±3000	≥90%	≤1.08
mPEG-AC-40K*	40000±4000	≥90%	≤1.08
mPEG-Ms-2K	2000±200	≥95%	≤1.05
mPEG- Ms -3.4K*	3400±340	≥95%	≤1.05
mPEG- Ms -5K	5000±500	≥95%	≤1.05
mPEG- Ms -10K	10000±1000	≥90%	≤1.06
mPEG- Ms -20K	20000±2000	≥90%	≤1.08
mPEG- Ms -30K	30000±3000	≥90%	≤1.08
mPEG- Ms -40K*	40000±4000	≥90%	≤1.08
R-PEG-R
Bi-NH₂-2K	2000±200	≥95%	≤1.05
Bi-NH₂-3.4K	3400±340	≥95%	≤1.05
Bi-NH₂-4K	4000±400	≥95%	≤1.05
Bi-NH₂-6K	5000±500	≥95%	≤1.05
Bi-NH₂-10K	10000±1000	≥90%	≤1.06
Bi-NH₂-20K	20000±2000	≥90%	≤1.08
Bi-NH₂-30K*	30000±3000	≥90%	≤1.08
Bi-NH₂-40K*	40000±4000	≥90%	≤1.08
Bi-COOH-2K	2000±200	≥95%	≤1.05
Bi-COOH-3.4K	3400±340	≥95%	≤1.05
Bi-COOH-4K	4000±400	≥95%	≤1.05
Bi-COOH-6K	5000±500	≥95%	≤1.05
Bi-COOH-10K	10000±1000	≥95%	≤1.06
Bi-COOH-20K	20000±2000	≥90%	≤1.08
Bi-COOH-30K*	30000±3000	≥90%	≤1.08
Bi-COOH-40K*	40000±4000	≥90%	≤1.08
Bi-Mal-2K	2000±200	≥95%	≤1.05
Bi-Mal-3.4K	3400±340	≥95%	≤1.05
Bi-Mal-4K	4000±400	≥95%	≤1.05
Bi-Mal-6K	6000±600	≥95%	≤1.05
Bi-Mal-10K	10000±1000	≥95%	≤1.06
Bi-Mal-20K	20000±2000	≥90%	≤1.08
Bi-Mal-30K*	30000±3000	≥90%	≤1.08
Bi-Mal-40K*	40000±4000	≥90%	≤1.08
Bi-SC-2K	2000±200	≥95%	≤1.05
Bi-SC-3.4K	3400±340	≥95%	≤1.05
Bi-SC-4K	4000±400	≥95%	≤1.05
Bi-SC-6K	6000±600	≥95%	≤1.05
Bi-SC-10K	10000±1000	≥95%	≤1.06
Bi-SC-20K	20000±2000	≥90%	≤1.08
Bi-SC-30K*	30000±3000	≥90%	≤1.08
Bi-SC-40K*	40000±4000	≥90%	≤1.08
Bi-NHS-2K	2000±200	≥90%	≤1.05
Bi-NHS-3.4K	3400±340	≥90%	≤1.05
Bi-NHS-5K	5000±500	≥90%	≤1.05
Bi-NHS-10K	10000±1000	≥90%	≤1.06
Bi-NHS-20K	20000±2000	≥90%	≤1.08
Bi-NHS-30K	30000±3000	≥90%	≤1.08
Bi-NHS-40K*	40000±4000	≥90%	≤1.08
Multi-arm-PEG
4-arm-PEG-5K	5000±500		≤1.05
4-arm-PEG-10K	10000±1000		≤1.06
4-arm-PEG-20K	20000±2000		≤1.07
4-arm-PEG-30K	30000±3000		≤1.08
4-arm-PEG-40K	40000±4000		≤1.08
4-arm-NH₂-5K	5000±500		≤1.05
4-arm-NH₂-10K	10000±1000		≤1.06
4-arm-NH₂-20K	20000±2000		≤1.07
4-arm-NH₂-30K	30000±3000		≤1.08
4-arm-NH₂-40K	40000±4000		≤1.08
4-arm-Mal-5K	5000±500		≤1.05
4-arm-Mal-10K	10000±1000		≤1.06
4-arm-Mal-20K	20000±2000		≤1.07
4-arm-Mal-30K	30000±3000		≤1.08
4-arm-Mal-40K	40000±4000		≤1.08
4-arm -COOH-5K	5000±500		≤1.05
4-arm-COOH-10K	10000±1000		≤1.06
4-arm-COOH-20K	20000±2000		≤1.07
4-arm-COOH-30K	30000±3000		≤1.08
4-arm-COOH-40K	40000±4000		≤1.08
4-arm-NHS-5K	5000±500		≤1.05
4-arm-NHS-10K	10000±1000		≤1.06
4-arm-NHS-20K	20000±2000		≤1.07
4-arm-NHS-30K	30000±3000		≤1.08
4-arm-NHS-40K	40000±4000		≤1.08
R1-PEG-R2
HO-PEG-NH₂-2K	2000±200	≥95%	≤1.05
HO-PEG-NH₂-3.4K	3400±340	≥95%	≤1.05
HO-PEG-COOH-2K	2000±200	≥95%	≤1.05
HO-PEG-COOH-3.4K	3400±340	≥95%	≤1.05
NH₂-PEG-COOH-2K	2000±200	≥95%	≤1.05
Acryl-PEG-NHS-2K	2000±200	≥95%	≤1.05
Acryl-PEG-NHS-3.4K	3400±340	≥95%	≤1.05

Seebio Biotech, Inc.
11-502. Lane 299, Bisheng Rd.
Zhangjiang High Tech Park
Shanghai 201204, P.R.China
Tel: 86-21-50272981
For customers' complaint or suggestion: 86-21-50272981-6821, 6818
Web: www.seebio.cn
Email: lifesci3@seebio.cn; fyland@seebio.cn
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