Description
High fat rodent diet with 1.25% cholesterol.
High fat rodent diet with 1.25% cholesterol.
Used in Research
Atherosclerosis
Often used with Apo E or LDLR knockout mice
Replaces
D12108 with used alcohol-extracted casein, which is not believed to be important in inducing an athero phenotype.
Packaging
Product is packed in 12.5 kg box.
Each box is identi ed with the product name, description, lot number and expiration date.
Lead Time
5-7 business days.
Gamma-Irradiation
Yes. Add 10 days to delivery time.
Form
Pellet, Powder
Shelf Life
Most diets require storage in a cool dry environment. Stored correctly they should last 6 months.
Because of the high fat content is best if kept frozen.
Atherosclerosis
Often used with Apo E or LDLR knockout mice
Replaces
D12108 with used alcohol-extracted casein, which is not believed to be important in inducing an athero phenotype.
Packaging
Product is packed in 12.5 kg box.
Each box is identi ed with the product name, description, lot number and expiration date.
Lead Time
5-7 business days.
Gamma-Irradiation
Yes. Add 10 days to delivery time.
Form
Pellet, Powder
Shelf Life
Most diets require storage in a cool dry environment. Stored correctly they should last 6 months.
Because of the high fat content is best if kept frozen.
Reference listing
Lichtman AH, Clinton S et al. Hyperlipidemia and Atherosclerosclerotic Lesion Development in LDL Receptor-Deficient Mice Fed Defined Semi purified Diets With and Without Cholate. Arteriosclerosis, Thrombosis and Vascular Biology. 1999; 19:1938-1944.- Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos J-C, Connelly PW, & Milstone DS. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J. Clin. Invest. 107:1255-1262, 2001.
- Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation. 2006 Jul 4;114(1):55-62. Epub 2006 Jun 26.
- Xie D, Hazarika S, Andrich AJ, Padgett ME, Kontos CD, Donatucci CF, Annex BH. High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue. J Sex Med. 2008 May;5(5):1137-48.
- Aslanian AM, Charo IF. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation. 2006 Aug 8;114(6):583-90. Epub 2006 Jul 31.
- Chiba T, Shinozaki S, Nakazawa T, Kawakami A, Ai M, Kaneko E, Kitagawa M, Kondo K, Chait A, Shimokado K. Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice. Atherosclerosis. 2008 Jan;196(1):68-75. Epub 2007 Mar 23.
- Martens GW, Arikan MC, Lee J, Ren F, Vallerskog T, Kornfeld H. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun. 2008 Aug;76(8):3464-72. Epub 2008 May 27.
- Wolfrum S, Teupser D, Tan M, Chen KY, Breslow JL. The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18601-6. Epub 2007 Nov 15.
- Trogan E, Feig JE, Dogan S, Rothblat GH, Angeli V, Tacke F, Randolph GJ, Fisher EA. Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3781-6. Epub 2006 Mar 1.
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