血液中急性時相反應蛋白顯著增加是發炎，組織損傷或感染的結果，可被用于判斷疾病級數的生物標志物。在不同物種中，急性生物標志物的反應不同。比如：C- 反應蛋白(CRP)在人體中會增加1000倍，而在大鼠中僅增加50%。恰恰相反，alpha-2巨球蛋白在大鼠中會增加100倍，而在人體中不會增加。

西寶生物供應美國進口用于檢測小鼠，大鼠，兔，狗，豬，牛，雞和猴急性時相反應蛋白包括CRP,觸珠蛋白，血紅素結合蛋白，alpha-1酸性糖蛋白，叢生蛋白，alpha-2巨球蛋白的ELISA試劑盒。

 相關ELISA試劑盒產品：

應用我們的ELISA試劑盒檢測大鼠血清脂多糖中急性時相反應蛋白的水平，結果見下圖和表格。

應用聲明：所有產品僅用于科研，不能應用于診斷和治療。

引用急性時相反應蛋白ELISA 試劑盒的相關文獻

Chicken alpha-1-acid glycoprotein

1. Lee KW, et al. Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens. Poultry Science. 89: 203-216 (2010)
2. Li G, et al. Immunopathology and cytokine responses in commercial broiler chickens with gangrenous dermatitis. Avian Pathology. 39(4): 255-264 (2010)

Dog CRP

1. Kjelgaard-Hansen M, et al. Measurement of serum interleukin-10 inthe dog. The Veterinary Journal. 173(2) 361-365 (2007)
2. Freeman LJ, et al. Comparison of pain and postoperative stress in dogs undergoing natural orifice transluminal endoscopic surgery, laparoscopic, and open oophorectomy. Gastrointest Endosc. 72(2):373-380 (2010)

Monkey Acute Phase Proteins

1. Ossetrova NI, et al. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole body radiation model. Radiation Measurements. 42: 1158-1163 (2007) – CRP
2. Blackwood RS, et al. Effects of the Macrolide drug Tylosin on Chronic Diarrhea in Rhesus Macaques (Macaca mullata). Comparative Medicine. 58(1): 81-87 (2008) – CRP
3. Blakely WF, et al. Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications. Health Phys. 98(2): 153-159 (2010) – CRP
4. Ossetrova NI, et al. C-reactive protein and serum amyloid-A as early-phase and prognostic indicators of acute radiation exposure in nonhuman primate total-body irradiation model. Radiation Measurements. 46: 1019-1024 (2011) – CRP & SAA
5. Hopkins RA, et al. Bioengineered human and allogeneic pulmonary valve conduits chronically implanted orthotopically in baboons: Hemodynamic performance and immunologic consequences. J Thorac Cardiovasc Surg. [Epub ahead of print] (2012) – CRP
6. Henning LN, et al. Pathophysiology of the rhesus macaque model for inhalational brucellosis. Infect Immun. 80(1):298-310 http://iai.asm.org/content/80/1/298.long (2012) – CRP

Mouse Acute Phase Proteins

1. Ito R, et al. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clinical and Experimental Immunology. 146: 330-338 (2006) – Haptoglobin
2. Bishop DF, et al. Uroporphyrinogen III synthase Knock-In mice have the human congenital erythropoietic porphyria phenotype, including the characteristic light-Induced cutaneous lesions. Am J Hum Genet. 78(4): 645-658 (2006) – Haptoglobin
3. Liu M, et al. Acute kidney injury leads to brain inflammation and functional changes. J Am Soc Neprol. 19(7): 1360-1370 (2008) - CRP
4. Chung M-C, etal. Activation of plasminogen activator inhibitor implicates protease InhA in the acute-phase response to Bacillus anthracis infection. J Med Microbiol. 58: 737-744 (2009) – CRP, Haptoglobin, Hemopexin & SAA
5. Bem RA, et al. Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection. Am J Physiol Lung Cell Mol Physiol 296: L46–L56 (2009) - Macroglobulin
6. Hod EA, et al. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood 115(21): 4284-4292 (2010) – SAA
7. Bem RA, et  al. Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice. The Journal of Immunology. 184: 931-938 (2010) – Macroglobulin
8. Cray C, et.al. Quantitation of acute phase proteins and protein electrophoresis in monitoring the acute inflammatory process in experimentally and naturally infected mice.  Comparative Medicine. 60(4): 263-371 (2010) – CRP, Haptoglobin & SAA
9. Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 ina mouse model of arthritis. Biochem Biophys Res Commun. 391(1):1080-1086 (2010) – SAA
10. Iversen PO, et al. Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure. Am J Physiol Regul Integr Comp Physiol. 298(3):R808-R814 http://ajpregu.physiology.org/content/298/3/R808.long (2010) – CRP
11. Teupser D, et al. No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. J Biol Chem. 286(8): 6272-6279 (2011) - CRP
12. Higashisaka K, et al. Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials. Biomaterials. 32: 3-9 (2011) - CRP, Haptoglobin & SAA
13. Lee KH, et al. Effects of Lonicera japonica Thunb. On dextran sulfate sodium-induces experimental colitis in mice. J Medicinal Plants Research. 5(22) 5437-5443 (2011) – SAA
14. Stanton MC, et Al. Inflammatory signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. http://www.journal-inflammation.com/content/8/1/8 (2011) – SAA
15. Matsumoto M, et al. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production. PLoS One. 2011; 6(8): e23652. 10.1371/journal.pone.0023652 (2011) – Haptoglobin
16. Beachy SH, et al.  Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Blood. 120(5): 1048-1059 (2012) – CRP
17. Yamasaki Y, et al. Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype. Vet Microbiol. [Epub ahead of print] (2012) – CRP
18. Sunami Y, et al. Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology. 56(3):1117-1128 (2012) – SAA
19. Yu B, et al. Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice. Transfusion. 52(7):1410-1422 (2012) – Haptoglobin & Hemopexin
20. van Ampting MT, et al. Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice. Infect Immun. 80(3):1115-1120 http://iai.asm.org/content/80/3/1115.long (2012) – SAA
21. Higashisaka K, et al. Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles. Nanoscale Res Lett. 7(1): 555 http://link.springer.com/article/10.1186/1556-276X-7-555/fulltext.html (2012) – Hemopexin
22. Aviello G, et al. A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner. Phytother Res. [Epub ahead of print] (2013) – SAA

Pig Acute Phase Proteins

1. Patterson JK, et al. Dietary Inulin Supplementation does not promote colonic iron absorption in a porcine model. J Agric Food Chem. 57: 5250-5256 (2009) – Haptoglobin
2. Pomorska-Mól M, Markowska-Daniel I, Kwit K. Immune and acute phase response in pigs experimentally infected with H1N2 swine influenza virus. FEMS Immunol Med Microbiol. [Epub ahead of print] (2012) – CRP & Haptoblobin
3. Kreuzer S, et al. No beneficial effects evident for Enterococcus faecium NCIMB10415 inweaned pigs infected with Salmonella enterica serovar Typhimurium DT104. Appl Environ Microbiol. 78(14):4816-4825 (2012) – Haptoglobin
4. Pomorska-Mól M, Kwit K, Markowska-Daniel I. Major acute phase proteins in pig serum from birth to slaughter. Bull Vet Inst Pulawy. 56: 553-557 (2012) - CRP & Haptoblobin
5. Pomorska-Mól M, Markowska-Daniel I, Kwit K. Acute phase protein response in pigs experimentally co-infected with swine influenza virus and Bordetella bronchiseptica. Centr Eur J Immunol. 37(3):221-226 http://www.termedia.pl/Experimental-immunology-Acute-phase-protein-response-in-pigs-experimentally-co-infected-with-swine-influenza-virus-and-Bordetella-bronchiseptica-,10,19478,1,1.html (2012) - CRP & Haptoblobin

Rabbit CRP

1. Qian Z, et al. Targeting vascular injury using hantavirus-pseudotyped lentiviral vectors. Molecular Therapy 13(4): 694-704 (2006)
2. Cenesiz S, et al. Effects of fluoride on C-reactive protein, adenosine deaminase, and ceruloplasmin in rabbit sera. Research Report Fluoride 41(1): 52-56 http://www.fluorideresearch.org/411/files/FJ2008_v41_n1_p052-056.pdf  (2008)
3. Ferrian S, et al. Comparison of immune response to lipopolysaccharide of rabbit does selected for litter size at weaning or founded for reproductive longevity. Res Vet Sci [Epub ahead of print] (2013) 

Rat Acute Phase Proteins

1. Bledsoe SL, et al. Pravastatin and clpidogrel combined inhibit intimal htperplasia in a rat carotid endarterectomy model. Vasc Endovasc Surg. 40: 49-57 (2006) – CRP
2. Schouw Nielsem S, et. al. Synthesis of acute phase proteins in rats with cirrhosis exposed to lipopolysaccharide. http://www.comparative-hepatology.com/content/5/1/3  (2006) – Alpha-1-acid glycoprotein, Haptoglobin
3. Aller M-A, et al. Plasma redox status is impaired in the portacaval shunted rat – the risk for reduced antioxidant ability. http://www.comparative-hepatology.com/content/7/1/1 (2008) – Thiostatin
4. Kiraly MA, et al. Exercise maintains euglycemia in association with decreased activation of c-jun NH2-terminal kinase and serine phosphorylation of IRS-1 inthe liver of ZDF rats. Am J Physiol Endocrinol Metab 289: E671-E682 (2010) – Haptoglobin
5. Ansede JH, et al. Characterization of sandwich-cultured hepatocytes as an in vitro model to assess the hepatobiliary disposition of copper. Am Soc Pharm Exp Ther. 37(5): 969-976 (2009) – Ceruloplasmin
6. Gillet A, et al. TNF production in macrophages is genetically determined and regulates inflammatory disease in rats. J Immunol. 185: 442-450 (2010) – Alpha-1-acid glycoprotein
7. Hino S, et al. Ameliorating effects of short-chain inulin-like fructans on the healing stage of trinitrobenzene sulfonic acid-induced colitis in rats. Biosci Biotechnol Biochem. 75(11): 2169-2174 http://dx.doi.org/10.1271/bbb.110460 (2011) – Alpha-1-acid glycoprotein
8. Tomofuji T, et al. Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats. Biomed Res. 32(5):343-349 http://dx.doi.org/10.2220/biomedres.32.343 (2011) – CRP
9. D’souza AM, et al. Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids. Am J Physiol Gastrointest Liver Physiol.  301(8):G850-G863 (2012) – Haptoglobin

其他產品：

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研究生物技術藥物的免疫毒性ELISA試劑盒

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