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西寶生物
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Nature:揭示攝入更多乳酸的黑色素瘤細胞是轉移高手
在一項新的研究中,來自美國德克薩斯大學西南醫學中心的研究人員發現某些黑色素瘤細胞更可能在體內擴散的原因。這一發現開辟了一種潛在的新治療途徑,并且可能用于幫助減少從3期黑色素瘤進展為更加致命的4期黑色素瘤的患者比例。相關研究結果近期發表在Nature期刊上,論文標題為“Metabolic heterogeneity confers differences in melanoma metastatic potential”。論文通訊作者為德克薩斯大學西南醫學中心兒童醫學中心研究所主任Sean Morrison博士和德克薩斯大學西南醫學中心兒童醫學中心研究所教授Ralph DeBerardinis博士。[查看]
http://m.baichuan365.com/Article/naturejssrgdrsdhsslx_1.html
Nat Med:利用多能性干細胞移植在動物中生長出功能齊全的肺部
在一項新的研究中,來自美國哥倫比亞大學的研究人員能夠使用移植的干細胞在小鼠胚胎中生長出功能齊全的肺部。這一發現表明人們最終有可能使用這種技術在動物中為需要肺部移植的患者生長出人肺部,以及研究新的肺部治療方法。相關研究結果于2019年11月7日在線發表在Nature Medicine期刊上,論文標題為“Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells”。[查看]
http://m.baichuan365.com/Article/natmedlydnxgxbyzzdwz_1.html
Acta Neuropathol:揭示帕金森病在腦細胞之間擴散新機制
在一項新的研究中,來自瑞典林雪平大學、卡羅林斯卡研究所、烏普薩拉大學和德國埃爾蘭根大學醫院的研究人員發現,神經細胞之間的較小通道參與了一種新發現的關于帕金森病如何在大腦中擴散的機制。這些結果表明有害的蛋白聚集物或者說沉積物能夠結合通道形成蛋白并“搭便車”,并以這種方式擴散至健康細胞。相關研究結果近期發表在Acta Neuropathologica期刊上,論文標題為“Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes”。[查看]
http://m.baichuan365.com/Article/actaneuropatholjspjs_1.html
Nature:揭示卵細胞選擇最健康的線粒體傳遞給后代的機制
發育中的卵細胞會進行測試,選出最健康的線粒體(細胞中的能量制造工廠),然后傳遞給下一代。一項針對果蠅的新研究顯示了這種測試是如何進行的。相關研究結果于2019年5月15日在線發表在Nature期刊上,論文標題為“Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline”。[查看]
http://m.baichuan365.com/Article/naturejslxbxzzjkdxlt_1.html
國際聯合委員會在東京舉辦評審和質量改進見習培訓會
國際聯合委員會(Joint Commission International,簡稱JCI)宣布將于2018年12月3-7日舉辦東京國際評審和質量改進見習培訓會(Tokyo International Practicum on Accreditation and Quality Improvement)。為幫助希望取得JCI認證的醫療保健組織做好準備工作,這項全面的教育計劃會詳細解釋JCI的方法和標準,并重點介紹要通過認證和成功做到以患者為中心需要遵循的最佳實踐和流程。[查看]
http://m.baichuan365.com/Article/gjlhwyhzdjjbpshzlgjj_1.html
Science:揭示天然的多反應性IgA識別微生物群機制
IgA被認為包被著駐留在腸道中的共生微生物群(commensal microbiota),并且抵抗腸道病原菌。IgA反應是在正常的穩態條件下發生的,而且在諸如派爾集合淋巴結(Peyer’s patches)之類的粘膜相關淋巴組織中參與T細胞依賴性的和T細胞不依賴性的分化通路。然而,盡管穩態IgA(homeostatic IgA)是大量存在的,但是它的反應特異性長期以來卻是未知的。[查看]
http://m.baichuan365.com/Article/sciencejstrddfyxigas_1.html
Science:高通量分析上千種微型蛋白,有望引發蛋白工程變革
在一項新的研究中,來自美國華盛頓大學和加拿大多倫多大學的研究人員報道了一種新的高通量方法使得對計算設計蛋白(computationally designed protein,即利用計算方法設計蛋白)的折疊穩定性進行最大規模的測試成為可能。[查看]
http://m.baichuan365.com/Article/sciencegtlfxsqzwxdby_1.html
FDA批準首個非小細胞肺癌(NSCLC)血液樣本基因檢測試劑盒
瑞士制藥巨頭羅氏(Roche)近日宣布,美國食品和藥物管理局(FDA)已批準cobas EGFR Mutation Test v2(cobas EGFR突變檢測試劑盒v2),這是一款以血液為基礎的、用于抗癌藥特羅凱(Tarceva,通用名:erlotinib,厄洛替尼)的伴隨診斷試劑盒。值得一提的是,這是FDA批準的首個以血液為基礎、用于檢測非小細胞肺癌(NSCLC)患者表皮生長因子受體(EGFR)基因突變的基因檢測試劑盒。據估計,這類突變存在于10-20%的NSCLC病例。[查看]
http://m.baichuan365.com/Article/fdapzsgfxxbfansclcxy_1.html
理想的腎功能評估新指標——【胱抑素C】 | 「西寶生物」
胱抑素C(CysC, cystatin C)是一種低分子量、堿性非糖化的分泌型蛋白質,與腎小球濾過率(GFR)有良好的相關性 ,可將其作為GFR 的替代指標用于各種亞臨床及臨床腎病的診斷。西寶生物作為診斷原料行業的供應商,提供胱抑素C檢測試劑盒所需的抗原及抗體。[查看]
http://m.baichuan365.com/Article/lxdsgnpgxzbgyscxbsw_1.html
科學家發現癌基因S<font color='red'>TAT</font>3竟也可抑癌?!
奧地利維也納醫科大學的研究人員發現,通常在癌癥中發揮癌基因作用的IL-6和STAT3信號途徑在前列腺癌中發揮著不同的作用。激活的STAT3能夠激活ARF基因,阻斷細胞分裂進而抑制細胞生長。[查看]
http://m.baichuan365.com/Article/kxjfxajystat3jykya_1.html
乳酸快速檢測試劑盒, D-/L-Lactic Acid (D-/L-Lactate) (Rapid) Assay Kit, 貨號:K-DLATE
Megazyme提供乳酸檢測試劑盒, 貨號:K-DLATE[查看]
http://m.baichuan365.com/Article/K-DLATE_1.html
蛋白類產品、鏈酶親和素和生物素衍生物
蛋白A、蛋白G和蛋白L是微生物來源的天然或重組蛋白質,可以和哺乳動物的免疫球蛋白結合。將這些蛋白偶聯于支持物上,利用親和層析來純化抗體,也可用于免疫沉淀(Immunoprecipitation, IP)或免疫共沉淀(Co-IP)。不同的抗體結合蛋白與不同的免疫球蛋白的結合能力并不一樣,它們受到后者的來源及亞類的影響,因此對于不同的抗體需要選擇不同的抗體結合蛋白。[查看]
http://m.baichuan365.com/Article/376_1.html
記錄總數:177 | 頁數:12  <...3456789101112
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