Brief

Name

Cetylpyridinium chloride monohydrate (CPC)

Alternative Names

Pyridinium, 1-hexadecyl-, chloride, monohydrate; acetoquatcpc； 1-hexadecyl-pyridiniuchloride; 1-palmitylpyridiniumchloride;

CAS #

6004-24-6

EINECS #

204-593-9

Formula

C₂₁H₄₀ClNO

m.w.

358.01

Properties

Appearance

White Powder

Melting Range

80 - 84 °C

Boiling Range

120 - 124 °C @ 0.09 hPa

Solubility in Water

Soluble (50 g/L @ 19.5°C)

Octanol/Water Coefficient:

Log Kow = 1.71

Application

CPC (Cetylpyridinium chloride or1-hexadecylpyridinium chloride) is a quaternary ammonium compound which demonstrates varying degrees of activity against bacteria. Compared to other antimicrobials, CPC is especially effective against Gram-positive bacteria.
The following list summarizes the broad antimicrobial features of CPC, based on lethal concentrations:

Gram-positive bacteria (e.g. Staphylococcus):

Highly sensitive

Gram-negative bacteria (e.g. Salmonella, E. coli):

moderately sensitive*

Mycobacteria (e.g. Mycobacterium tuberculosis):

insensitive

Bacterial spores (e.g. Bacillus, Clostridium):

insensitive

Fungi (e.g. Candida, Saccharomyces):

sensitive

Enveloped viruses (e.g. HIV, Hepatitis B):

sensitive

Non-enveloped viruses (e.g. Poliovirus):

insensitive

CPC is widely used in OTC products including mouthwash, throat lozenges, nasal sprays and antiseptic (first aid) creams and lotions. It is also used as active pharmaceutical ingredient and excipient in pharmaceutical products.

CPC meets requirements for the Monographs of the US, European and Japanese Pharmacopoeia.

Specification

Assay

≥99 %

Appearance

White Powder

Melting Range

80 - 84℃

Water

4.5%-5.5%

Residue on Ignition

≤0.2%

Heavy Metal

≤0.002%