單抗助力【GLP-1】及【Exendin-4】新功能探索

來源：作者：人氣：-發表時間：2016-08-10 12:10:00【大中小】

西寶生物代理BioPorto GLP-1及Exendin-4相關單克隆抗體。科學家們從希拉毒蜥唾液中分離得到一種肽類物質Exendin-4，它與哺乳動物GLP-1有53%的同源，N端的同源性更是高達80%。該多肽與GLP-1有同樣的促胰島素分泌的作用，且穩定性遠遠高于GLP-1。

GLP-1及Exendin-4的作用

GLP-1是由末端空腸、回腸和結腸的Langerhans細胞分泌的一種多肽，主要生理功能包括具有葡萄糖依賴的胰島素促泌作用。

由于GLP-1在人體內半衰期僅有2分鐘左右，可被二肽激肽酶(DPP-Ⅳ)快速降解而失去活性，其生物學效應受到很大限制。Exendin-4具有與GLP-1相似的生理功能，但Exendin-4的半衰期達9.57小時，在臨床應用時具有優勢，GLP-1及其受體激動劑Exendin-4成為具有廣闊應用前景。

GLP-1及Exendin-4的其它生理功能

GLP-1及Exendin-4可延遲胃的排空，引起胞脹感的產生并抑制食物的攝取；
GLP-1及Exendin-4對神經細胞有促增殖再生和抗凋亡的保護作用，可對抗多種因素引起的神經元氧化損傷，提示其將來可擴展到用于阿爾茲海默癥和帕金森等神經退行性疾病的研究；
GLP-1R在心臟區域也有表達，提示其在心臟也可能發揮某些生理功能。

BioPorto GLP-1單克隆抗體

BioPorto致力于開發疾病研究相關的單克隆抗體、抗原及診斷試劑盒。胰高血糖素樣肽-1(GLP-1) 存在多種剪切體，包括GLP-1 Extended form、GLP-1 Active form及GLP-1 Metabolite等：

貨號	產品名稱	規格	宿主	應用
ABS 033-04-02	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	200µl	Mouse	ELISA, IHC
ABS 033-04-1	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	1ml	Mouse	ELISA, IHC
ABS 033-10-02	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	200µl	Mouse	ELISA, WB
ABS 033-10-1	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	1ml	Mouse	ELISA, WB
ABS 033-10B-005	Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific)	50µl	Mouse	ELISA
ABS 044-49-02	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	200µl	Mouse	ELISA, WB
ABS 044-49-1	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	1ml	Mouse	ELISA, WB
ABS 044-53-02	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	200µl	Mouse	ELISA, WB
ABS 044-53-1	Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific)	1ml	Mouse	ELISA, WB
ABS 046-03-02	Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)	200µl	Mouse	ELISA, WB
ABS 046-03-1	Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)	1ml	Mouse	ELISA, WB
ABS 046-03B-005	Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific)	50µl	Mouse	ELISA
HYB 011-05-02	Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)	200µl	Mouse	ELISA, WB
HYB 011-05-1	Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific)	1ml	Mouse	ELISA, WB
HYB 147-06-02	Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)	200µl	Mouse	ELISA, IHC
HYB 147-06-1	Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)	1ml	Mouse	ELISA, IHC
HYB 147-06B-005	Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific)	50µl	Mouse	ELISA
HYB 147-08-02	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	200µl	Mouse	ELISA, WB
HYB 147-08-1	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	1ml	Mouse	ELISA, WB
HYB 147-08B-005	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	50µl	Mouse	ELISA
HYB 147-12-02	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	200µl	Mouse	ELISA, WB, IHC
HYB 147-12-1	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	1ml	Mouse	ELISA, WB, IHC
HYB 147-12B-005	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	50µl	Mouse	ELISA
HYB 147-13-02	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	200µl	Mouse	ELISA, WB
HYB 147-13-1	Glucagon-like peptide-1 (GLP-1, Mid-molecule specific)	1ml	Mouse	ELISA, WB
HYB 006-02-02	Glucagon-like peptide-2 (human, GLP-2)	200µl	Mouse	ELISA
HYB 006-02-1	Glucagon-like peptide-2 (human, GLP-2)	1ml	Mouse	ELISA

BioPorto Exendin-4單克隆抗體

貨號	產品名稱	規格	宿主	應用
ABS 012-20-02	Exendin-4	200µl	Mouse	ELISA
ABS 012-20-1	Exendin-4	1ml	Mouse	ELISA
ABS 012-24-02	Exendin-4	200µl	Mouse	ELISA
ABS 012-24-1	Exendin-4	1ml	Mouse	ELISA
ABS 012-35-02	Exendin-4	200µl	Mouse	ELISA
ABS 012-35-1	Exendin-4	1ml	Mouse	ELISA
ABS 012-35B-005	Exendin-4	50µl	Mouse	ELISA