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《PNAS》科學家解開細胞存活之謎
拉霍亞免疫研究所(LJI)的研究人員終于發現了一種名為O-GlcNAc轉移酶(OGT)的酶在維持細胞健康中的作用。這些發現發表在《美國國家科學院院刊》(Proceedings of The National Academies of Sciences)上,為細胞生物學提供了至關重要的見解,并可能為重大醫學突破鋪平道路。[查看]
http://m.baichuan365.com/Article/pnaskxjjkxbchzm_1.html
阿爾茲海默與表觀遺傳之間的聯系,干預“神經病”取得新進展
來自西奈山的科學家們對DNA甲基化在阿爾茨海默病(AD)中的作用提供了新的見解。根據他們的研究,DNA甲基化對AD相關基因和蛋白質的共表達網絡有顯著影響。因此,這可能會揭示新的神經病理過程和分子機制,最終導致阿爾茨海默病的創新治療干預措施的發展。[查看]
http://m.baichuan365.com/Article/aezhmybgyczjdlxgysjb_1.html
無路可退!主食中的農藥殘留,可誘發阿爾茨海默病
草甘膦是許多商業除草劑中的活性成分,是全球應用最廣泛的除草劑。在小麥、水稻、玉米和大豆等作物中使用草甘膦的增加與阿爾茨海默病(Alzheimer’s disease,AD)和其他神經退行性疾病導致的死亡率增加呈正相關。此外,草甘膦暴露會增加血漿中的促炎細胞因子,尤其是TNFα(Tumor necrosis factor α)。草甘膦已被證明可以穿過血腦屏障,但尚未在體內得到驗證。[查看]
http://m.baichuan365.com/Article/wlktzszdnyclkyfaechm_1.html
Science Advances新突破:快速高效生產人體免疫細胞的新方法
英屬哥倫比亞大學的一個研究小組開發了一種新的、快速、高效的方法,可以在實驗室中產生抗癌免疫細胞。這一發現可以幫助免疫細胞治療領域從昂貴的小眾轉變為易于擴展和廣泛適用的東西。研究小組發現,在發育的關鍵窗口期向干細胞提供兩種蛋白質,可以將免疫細胞的生產效率提高80倍。[查看]
http://m.baichuan365.com/Article/scienceadvancesxtpks_1.html
調查顯示,阿爾茨海默病研究正在迷失方向
阿爾茨海默病(AD)是一種復雜的神經退行性疾病。多年來,阿爾茨海默病的研究主要專注于少數病理改變,比如大腦中tau蛋白和β-淀粉樣蛋白的異常積累。近期的一項綜合調查表明,過去30年的研究主要集中于某些生物學通路(特別是免疫和代謝通路),但還有數百條通路與這種疾病有關。[查看]
http://m.baichuan365.com/Article/dcxsaechmbyjzzmsfx_1.html
別再emo了,情緒真的能夠改變基因!
一篇題為“DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress”的研究發表在Nature Communications,在哺乳動物細胞中發現了一種新的DNA腺嘌呤修飾,N(6)-甲基腺嘌呤(6mA)。[查看]
http://m.baichuan365.com/Article/bzemolqxzdnggbjy_1.html
劍指“癌中之王”!Science Advances:人工智能+多組學手段助力胰腺導管腺癌的早期檢測
代謝組學(metabolomics)可以收集、檢測和分析對生物活性和病理條件高度敏感的各種小分子代謝物,準確、穩健和低成本的代謝組學檢測方法為未來的疾病診斷提供了希望。近年來,越來越多的研究借助人工智能的方法,對組學數據進行分析并建立合適有效的檢測或驗證模型,應用于疾病診斷、分型及療效預測。[查看]
http://m.baichuan365.com/Article/jzazzwscienceadvance_1.html
全球首款“吸入式”新冠疫苗!接種就像“喝奶茶”,你想來一杯嗎?
近日,由上藥康希諾生產的首批新冠疫苗“克威莎”實現量產下線,年產2億劑。它是由康希諾生物與軍事科學院陳薇院士團隊合作研發的肌肉注射腺病毒載體重組新冠疫苗(5型腺病毒載體)(以下簡稱Ad5-nCoV),于今年2月25號在國內獲批附條件上市。1劑注射即可實現14天內的快速保護,單針接種意味著可實現人群大規模快速接種,對社會整體防疫策略意義重大。[查看]
http://m.baichuan365.com/Article/qqskxrsxgymjzjxhncnx_1.html
基礎科研 | 石墨烯 YYDS!Science Advances:石墨烯生物支架用于抑制器官移植的炎癥反應,提高移植細胞的生存率
2021年11月,來自斯坦福的研究者們在Science 子刊上發表題為:《Localized drug delivery graphene bioscaffolds forcotransplantation of islets and mesenchymal stem cells》的文章,報道了關于三維支架用于胰島細胞移植的近期工作進展。研究者們開發了一種可植入的石墨烯生物支架,這種支架具有良好的生物相容性并且可以攜帶地塞米松(Dex),使其成為局部消炎藥傳遞平臺,避免常規靜脈注射地塞米松的全身性的副作用,同時能夠精確地調節移植微環境中的炎癥反應。[查看]
http://m.baichuan365.com/Article/jckysmxyydssciencead_1.html
攻克阿爾茨海默癥的曙光!納米酶復合材料或可改善阿爾茨海默癥
阿爾茨海默病(AD)俗稱老年癡呆癥,是一種神經退行性疾病,是一種與淀粉樣蛋白原纖維(Aβ)沉積和神經纖維纏結(NFTs)密切相關的線粒體功能障礙。治療AD的藥物一直在開發,但是效果都很有限,主要原因是:對認知功能的影響較差或有顯著的副作用以及血腦屏障穿透性較弱,難以達到理想的治療效果。[查看]
http://m.baichuan365.com/Article/gkaechmzdsgnmmfhclhk_1.html
無需腎移植!Nature子刊:科學家通過逆轉小鼠多囊腎病揭示腎臟的可塑性
多囊腎,即正常腎組織被無數小囊所代替,外形似一串葡萄。可分為4型:①常染色體隱性多囊腎;②腎發育不良;③常染色體顯性多囊腎;④尿道梗阻多囊腎。其中常染色體顯性多囊腎又稱成人型多囊腎(ADPKD),發病率為1/500~1000。臨床特征包括充滿液體的囊腫的生長,使腎臟變形和擴大,并引發炎癥和纖維化等繼發性過程,這導致大多數患者出現腎功能衰竭。[查看]
http://m.baichuan365.com/Article/wxsyznaturezkkxjtgnz_1.html
【Nature】無需針頭注射!全球首款新冠DNA 疫苗獲批上市
據《Nature》雜志9月3日報道,印度于近日緊急授權批準了全球首款新冠DNA 疫苗“ZyCoV-D”,該疫苗由印度制藥公司ydus Cadila研發,無需針頭注射即可穿透皮膚,可以免除打針引起的疼痛。據悉,印度藥品監管機構已經批準該疫苗用于12歲及以上人群接種,并將于本月開始使用>,計劃到明年年初將能生產5000萬劑。[查看]
http://m.baichuan365.com/Article/naturewxztzsqqskxgdn_1.html
新發現:中國科學家發現瘧疾傳播的核心調控因子
2021年8月8日,同濟大學和江蘇省寄生蟲病防治研究所聯合研究,在國際期刊 Nucleic Acids Resreach上在線發表了題為“A cascade oftranscriptional repression determines sexual commitment and development inPlasmodium falciparum ”的文章,揭示了瘧疾傳播的核心調控因子。[查看]
http://m.baichuan365.com/Article/njdbytwnycnycdscxyrh_1.html
致死率提高82%!這些新冠變異毒株會成為下一個Delta嗎?
近日,Nature 發表了題為“Remember Beta? New data reveal variant’s deadly powers”的評論文章,引發了人們對 Beta 變種的關注。Beta(B.1.351) 變種最早是在2020年5月被發現于南非,曾在2020年年底在當地引發了第二波新冠疫情并擴散至全球。一些證據表明,Beta 引起的南非第二波疫情期間,COVID-19 的重癥病例比第一波時期更為常見。[查看]
http://m.baichuan365.com/Article/dqxgbdbydzdeltaxjqql_1.html
Science子刊重磅:致命性僅次COVID-19!“餓死”肺炎鏈球菌或能保命
近日,墨爾本大學領銜的科研團隊在《Science Advances》發表了一篇題為The structural basis of bacterial manganese import的文章,研究發現了一種通過“餓死”病原體對抗肺炎的新方法![查看]
http://m.baichuan365.com/Article/sciencezkzbzmxjccovi_1.html
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Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade II
D-乳酸脫氫酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮標準品
DADK嗪草酮標準品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化鋁 (Reduction Grade) 標準物質
氧化鋁 (Reduction Grade) 標準物質
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain