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不破不立?Science子刊揭示:遭遇致命打擊時(shí),癌細(xì)胞如何“吃自己”求生
近日,來自丹麥癌癥協(xié)會(huì)研究中心、哥本哈根大學(xué)以及南丹麥大學(xué)的研究人員在Science Advances發(fā)表了一篇的研究報(bào)告,指出癌細(xì)胞能夠通過大型胞飲作用(macropinocytosis),“吃掉”細(xì)胞受損區(qū)域從而在危急關(guān)頭存活下來。值得注意的是,研究人員還發(fā)現(xiàn)了一種獨(dú)特的膜重組機(jī)制,這為人們抑制癌細(xì)胞的擴(kuò)散、消滅腫瘤奠定了基礎(chǔ)。[查看]
http://m.baichuan365.com/Article/bpblsciencezkjszyzmd_1.html
舊藥可新用!Cell子刊揭示糖皮質(zhì)激素藥物相關(guān)副作用的遺傳位點(diǎn)
近日,來自賓夕法尼亞大學(xué)佩雷爾曼醫(yī)學(xué)院的Mitchell A. Lazar團(tuán)隊(duì)在Cell Metabolism上在線發(fā)表了題為“Individual-specific functional epigenomics reveals geneticdeterminants of adverse metabolic effects of glucocorticoids”的文章,揭示糖皮質(zhì)激素藥物相關(guān)副作用的遺傳位點(diǎn)。[查看]
http://m.baichuan365.com/Article/jykxycellzkjstpzjsyw_1.html
存在黑幕?Biogen阿爾茲海默癥新藥Aduhelm再遭批判,F(xiàn)DA高官要求啟動(dòng)聯(lián)邦調(diào)查
近日,局勢更加迷霧重重,F(xiàn)DA代理局長Janet Woodcock呼吁美國監(jiān)察長辦公室(Office of Inspector General,OIG)對(duì)批準(zhǔn)Aduhelm治療阿爾茲海默癥展開聯(lián)邦調(diào)查。[查看]
http://m.baichuan365.com/Article/czhmbiogenaezhmzxyad_1.html
Cell發(fā)文提出腫瘤治療新方向:藥物干預(yù)RNA剪接可增強(qiáng)腫瘤免疫
2021年6月24日,國際學(xué)術(shù)期刊《細(xì)胞》雜志在線發(fā)表了美國弗雷德哈欽森癌癥研究中心Robert K. Bradley和紀(jì)念斯隆凱特琳癌癥中心Omar Abdel-Wahab團(tuán)隊(duì)名為“Pharmacologic modulation of RNA splicing enhances anti-tumor immunity”的合作研究,該研究證實(shí)了藥物干預(yù)RNA剪接對(duì)抗腫瘤免疫的增強(qiáng)作用。[查看]
http://m.baichuan365.com/Article/cellfwtczlzlxfxywgyr_1.html
阻止認(rèn)知及聽力衰退,Plo Bio新文給出新思路:血液中的這種蛋白質(zhì)是關(guān)鍵
近日,美國德克薩斯大學(xué)麥戈文醫(yī)學(xué)院帶來的一項(xiàng)研究報(bào)告從分子機(jī)制上為人們了解影響衰老程度的關(guān)鍵因子提供了新的思路。文章指出,血液紅細(xì)胞中一種被稱為腺苷A2B受體(ADORA2B)的蛋白質(zhì)是抗衰老的關(guān)鍵成分之一,該蛋白質(zhì)的缺乏或過度消耗會(huì)加速人體功能組織衰老,造成記憶力快速下降、聽力退化以及大腦炎癥加劇。[查看]
http://m.baichuan365.com/Article/zzrzjtlstplobioxwgcx_1.html
KRAS抑制劑adagrasib獲FDA突破性療法認(rèn)定!
Mirati Therapeutics公司宣布,美國FDA已經(jīng)授予該公司開發(fā)的KRAS G12C抑制劑adagrasib突破性療法認(rèn)定,用于治療攜帶KRAS G12C突變的經(jīng)治非小細(xì)胞肺癌(NSCLC)患者。[查看]
http://m.baichuan365.com/Article/krasyzjadagrasibhfda_1.html
Nature 最新研究:硬核預(yù)防HIV,艾滋病還會(huì)是“不治之癥”嗎?
近日,美國俄勒岡健康與科學(xué)大學(xué)研究團(tuán)隊(duì)在 Nautre 子刊發(fā)表了題目為 Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission 的文章。其研究顯示,人源化CCR5單克隆抗體 Leronlimab 能夠有效預(yù)防恒河猴等非靈長類動(dòng)物感染猿/人HIV病毒,這一研究成果將為人類預(yù)防HIV病毒感染提供新的臨床治療途徑。[查看]
http://m.baichuan365.com/Article/naturezxyjyhyfhivazb_1.html
Nature 三連重磅!識(shí)破癌細(xì)胞的“詭計(jì)”,為結(jié)直腸癌患者帶來新希望
近日, 頂級(jí)學(xué)術(shù)期刊《Nature》三連發(fā)表重磅文章拆穿了癌細(xì)胞的“把戲”,為結(jié)腸癌高危人群提供了新的預(yù)防策略。同時(shí),《Nature》還在線發(fā)表題為Cancer stem cells in the gut have a bad influence on neighbouringcells的 News & Views,提供了有關(guān)癌細(xì)胞及其鄰近細(xì)胞在腸道中的競爭動(dòng)態(tài)的重要見解。[查看]
http://m.baichuan365.com/Article/natureslzbspaxbdgjwj_1.html
神奇!新研究揭示:神經(jīng)系統(tǒng)或可替代抗生素抑制細(xì)菌感染
近日,《Plos Pathogens》雜志發(fā)表了一篇題為UPEC kidney infection triggers neuro-immune communication leading to modulation of local renal inflammation by splenic IFNγ的文章,揭示了神經(jīng)系統(tǒng)感知局部細(xì)菌感染并迅速激活免疫反應(yīng)的新機(jī)制。[查看]
http://m.baichuan365.com/Article/sqxyjjssjxthktdkssyz_1.html
Cell子刊揭示:中藥成分可促進(jìn)脂肪產(chǎn)熱,或可用于治療肥胖
近日,國際學(xué)術(shù)期刊《細(xì)胞-代謝》在線發(fā)表了上海市第六人民醫(yī)院糖尿病研究所劉軍力課題組題為“The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity”的研究。該研究發(fā)現(xiàn),傳統(tǒng)中藥貫葉連翹的提取物貫葉金絲桃素能夠促進(jìn)脂肪組織產(chǎn)熱。[查看]
http://m.baichuan365.com/Article/cellzkjszycfkcjzfcrh_1.html
還在根據(jù)碳水含量選擇飲食?NEJM揭示:這個(gè)指標(biāo)才是重中之重
近日,NEJM在線發(fā)布了加拿大營養(yǎng)科學(xué)部的研究人員題為Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality的研究成果。該研究通過大量數(shù)據(jù)隨訪揭示了來自五大洲的不同收入水平的人群中血糖指數(shù)與心血管疾病之間關(guān)系,填補(bǔ)了低收入和中等收入國家關(guān)于這一方面研究的空白。[查看]
http://m.baichuan365.com/Article/hzgjtshlxzysnejmjszg_1.html
糖尿病患者的福音來了!《BMC》發(fā)文:NCAS可作為飲食糖替代品
近日,《BMC》發(fā)布了一篇題為High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice的文章,發(fā)現(xiàn)人和小鼠短期內(nèi)食用糖精量在最大可接受水平(ADI)時(shí),不會(huì)改變其腸道菌群穩(wěn)態(tài)或引起葡萄糖耐受不良。[查看]
http://m.baichuan365.com/Article/tnbhzdfyllbmcfwncask_1.html
Nature子刊:想要健康減肥,首選低脂高碳水飲食,還是高脂低碳水飲食?
近日,來自美國國立糖尿病、消化與腎臟疾病研究所和美國國立衛(wèi)生研究院的科研人員在《Nature Medicine》上發(fā)表了題為Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake的研究成果,發(fā)現(xiàn)相比動(dòng)物性低碳水高脂飲食,植物性低脂高碳水飲食每天攝入的能量更少,但胰島素和血糖水平確實(shí)更高。[查看]
http://m.baichuan365.com/Article/naturezkxyjkjfsxdzgt_1.html
Cell子刊:減肥能增加骨質(zhì)量,或成新的抗骨質(zhì)疏松治療策略
2020年10月6日,美國華盛頓大學(xué)醫(yī)學(xué)院 Steven L. Teitelbaum 團(tuán)隊(duì)在國際學(xué)術(shù)期刊《 細(xì)胞—代謝 》上發(fā)表題為“ Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain ”的文章,揭示了 成年小鼠脂肪細(xì)胞的消除能夠誘導(dǎo)大量的骨增加。[查看]
http://m.baichuan365.com/Article/cellzkjfnzjgzlhcxdkg_1.html
Nature子刊:超5萬人研究發(fā)現(xiàn)人體內(nèi)神奇的棕色脂肪可預(yù)防多種慢性疾病!
近日,來自美國洛克菲勒大學(xué)的研究人員在《Nature Medicine》上發(fā)表了題為Brown adipose tissue is associated with cardiometabolic health的研究成果,在這項(xiàng)超過52,000名參與者的大規(guī)模研究中,明確了BAT在促進(jìn)心腦血管代謝健康中具有潛在作用,含有BAT個(gè)體的心血管疾病及2型糖尿病等的患病風(fēng)險(xiǎn)明顯較低。[查看]
http://m.baichuan365.com/Article/naturezkc5wryjfxrtns_1.html
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Gadolinium 2-5% HNO3 (v/v) 10,000ug/mL
Gadolinium 2-5% HNO3 10,000ug/mL
Gadolinium 2-5% HNO3 10,000ug/mL
Lead 2-5% HNO3 100ug/mL
Lead 2-5% HNO3 100ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 1000ppm in 2% HNO3
Lead 1000ppm in 2% HNO3
Lead 2 - 5% HNO3 (v/v) 10,000ug/mL
Lead 2 - 5% HNO3 (v/v) 10,000ug/mL
Palladium 100ppm in 5% HCl
Palladium 100ppm in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 10,000ug/mL in 5% HCl
Palladium 10,000ug/mL in 5% HCl
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade II
D-乳酸脫氫酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮標(biāo)準(zhǔn)品
DADK嗪草酮標(biāo)準(zhǔn)品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化鋁 (Reduction Grade) 標(biāo)準(zhǔn)物質(zhì)
氧化鋁 (Reduction Grade) 標(biāo)準(zhǔn)物質(zhì)
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain