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脂質過氧化研究的新工具 - LipiR<font color='red'>AD</font>ICAL Green(檢測試劑)/OH-Pen(抑制物質)
LipiRADICAL Green是特異性熒光檢測脂質過氧化反應的上游因子脂質自由基的試劑。可用于活細胞成像、樣品中脂質自由基含量的相對定量以及樣品中脂質自由基的結構分析和鑒定。另外,OH-Pen還可作為脂質自由基特異性中和劑使用。[查看]
http://m.baichuan365.com/Article/LipiRADICAL_Green_1.html
抗dFoxO多克隆抗體
Forkhead 轉錄因子 FoxO 控制參與細胞周期,細胞死亡,代謝和氧化應激的各種細胞過程。 最近的研究還提示 FoxO 是各種生物體的壽命調節的關鍵分子。 果蠅具有單個 FoxO基因(dFoxO),其失活對于存活不構成影響。 然而,dFoxO 似乎調節抵抗氧化應激和果蠅的衰老。 由于 dFoxO 的活性受磷酸化,泛素化和乙酰化調節,在使用該抗體的免疫印跡實驗中可能出現多個 dFoxO 的條帶。 該抗體可檢測總 dFoxO 蛋白的內源水平。[查看]
http://m.baichuan365.com/Article/anti-dFoxO_1.html
Nature:利用CRISPR,終于弄清楚了一種獨特的免疫細胞是如何識別并摧毀腫瘤的
γ-δT細胞是免疫系統中的一種特殊類型的細胞,在識別和殺死癌細胞方面非常有效。腫瘤中這些T細胞水平較高的癌癥患者往往比那些水平較低的患者情況要好。但科學家們一直在努力弄清楚γ-δT細胞是如何識別癌細胞的,以及新的癌癥療法如何能夠利用這些強大的免疫細胞。現在,Gladstone研究所和加州大學舊金山分校的研究人員已經確定了γ-δT細胞識別癌細胞的條件。這項研究發表在《自然》雜志上。[查看]
http://m.baichuan365.com/Article/20230901_1.html
肺癌腦轉移的新機制
2023年8月17日,廣州醫科大學何建行及克利夫蘭診所鮑仕登共同通訊在Cancer Cell 在線發表題為“CD44+ lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration”的研究論文,該研究表明報道了肺腺癌(ADC)中來自CD44+肺癌干細胞(CSCs)的血管周細胞通過G蛋白偶聯受體124 (GPR124)增強的跨內皮遷移(TEM)引起腫瘤腦轉移。[查看]
http://m.baichuan365.com/Article/fanzydxjz_1.html
Science:第一次確定了監督tau功能的基因
根據賓夕法尼亞大學佩雷爾曼醫學院的一項新研究,一種編碼與tau蛋白產生相關的蛋白的基因:TRIM11,在類似阿爾茨海默病(AD)的神經退行性疾病的小動物模型中被發現可以抑制惡化,同時提高認知和運動能力。此外,TRIM11被確定在去除導致神經退行性疾病(如AD)的蛋白纏結中起關鍵作用。研究結果發表在《科學》雜志上。[查看]
http://m.baichuan365.com/Article/sciencedycqdljdtaugn_1.html
脂聯素 糖尿病早期篩查的“新指標”
脂聯素(ADPN)是由脂肪細胞分泌的、對人體有保護作用的特異性脂肪因子,人脂聯素由244個氨基酸組成,是一種血漿含量相對豐富的蛋白,其基因位于染色體3q27,這也是糖尿病易感基因所在處,相對分子質量為30KD,是一種具有調節糖脂代謝、抗炎癥反應、抗動脈粥樣硬化等多重效應的脂肪細胞因子。[查看]
http://m.baichuan365.com/Article/zlstnbzqscdxzb_1.html
阿爾茲海默癥早期診斷標志物
阿爾茲海默癥的檢測主要有: 影像學檢查、 腦脊液檢測、神經心理學測驗、腦電圖檢查。 AD早期診斷的生物標志物:Aβ42、Аβ42/ Aβ40、APPr、Aβ寡聚體、T-tau、P-tau、AD7c-NTP、NFL、VLP-1、hFABP、TGF-?、YKL-40、PGE2、IsoPs、miRNA-342-3p、Ferritin、Pb4等[查看]
http://m.baichuan365.com/Article/aezhmzzqzdbzw_1.html
IL-17蛋白對皮膚老化的關鍵作用
來自巴塞羅那生物醫學研究所(IRB Barcelona)與國家基因組分析中心(CNAG)合作的一組科學家發現,IL-17蛋白在皮膚老化中起著核心作用。這項研究由巴塞羅那IRB的Guiomar Solanas博士、Salvador Aznar Benitah博士和CNAG的Holger Heyn博士領導,強調了Il -17介導的衰老過程到炎癥狀態。[查看]
http://m.baichuan365.com/Article/il17dbdpflhdgjzy_1.html
Science Advances:肝細胞影響生物鐘的又一證據
昆士蘭大學領導的一項研究表明,肝細胞會影響人體內部的生物鐘,而此前人們認為生物鐘完全由大腦控制。昆士蘭大學分子生物科學研究所的fracimdsamric Gachon副教授和法國巴黎城市大學/CNRS的Serge Luquet博士及其合作者已經證明,移植了人類肝細胞的小鼠具有改變的晝夜節律。這項研究發表在《Science Advances》雜志上。[查看]
http://m.baichuan365.com/Article/scienceadvancesgxbyx_1.html
血小板聚集功能檢測——誘聚劑
血小板聚集是血小板的主要功能之一。 血小板在執行生理性止血作用的同時,在病理性血栓形成過程中起著先導而關鍵的作用,因此,檢測血小板聚集功能對早期發現是否有血 栓形成的危險存在以及闡明相關疾病的機制等有重要意義。然而,僅采用單一誘聚劑檢測時,可能無法完整的反映體檢者的實際情況。西寶生物提供多種誘導血小板聚集的誘聚劑,包括膠原(Collagen)、花生四烯酸(arachidonicacid, AA)、二磷酸腺苷(adenosine diphosphate, ADP)和瑞斯托霉素(ristomycin,RIS)[查看]
http://m.baichuan365.com/Article/AggregationAgents_1.html
Science子刊:世界首個能抵御致死性細菌感染的mRNA疫苗問世
近日,一篇發表在國際雜志Science Advances上題為“A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium”的研究報告中,來自以色列特拉維夫大學等機構的科學家們通過研究開發出了首個基于mRNA的疫苗,其或能100%有效抵御一種對人類致死的細菌。[查看]
http://m.baichuan365.com/Article/sciencezksjsgndyzsxx_1.html
腺苷脫氨酶(<font color='red'>AD</font>A)檢測試劑盒用原輔料
腺苷脫氨酶(ADA)測可以用于診斷多種疾病,如先天性免疫缺陷癥候群(SCID)、HIV感染、結核病、腫瘤和肝膽等。腺苷脫氨酶(ADA)含量的測定方法,有過氧化物酶法、谷氨酸脫氫酶法等。西寶生物可提供腺苷脫氨酶(ADA)檢測試劑盒用原輔料,咨詢服務熱線:400-021-8158或021-50272975。[查看]
http://m.baichuan365.com/Article/ADAtest_Materials_1.html
<font color='red'>AD</font>C Linker之單分散氨基PEG Linker系列
在藥物遞送中,PEG可以用作抗體-藥物偶聯物(ADC)的連接體,或者用作納米顆粒的表面涂層,以改善全身藥物遞送。研究發現,將單分散PEG插入小分子藥物中,可以增加藥物的溶解度和穩定性,從而延長藥物在體內的半衰期,并可以減少高分子量PEG修飾聚合物時的空間位阻和結合作用,從而降低免疫原性,改善藥代動力學,增加循環時間和降低毒性。[查看]
http://m.baichuan365.com/Article/ADCLINKER_PEG_1.html
Nature Methods:新的亮紅色熒光蛋白
熒光蛋白被廣泛應用于生物學研究,使各種類型的細胞或結構可見。例如,與癌癥有關的干細胞或蛋白質。由Dorus Gadella領導的阿姆斯特丹大學研究小組開發了一種新的鮮紅色熒光蛋白:mScarlet3。他們在權威雜志《自然方法》上發表了這種蛋白質的特性和DNA代碼。[查看]
http://m.baichuan365.com/Article/naturemethodsxdlhsyg_1.html
Nature子刊:血管周圍細胞誘發阿爾茨海默病相關的微膠質功能障礙
小膠質細胞是保護哺乳動物大腦的初級免疫細胞,部分是通過吞噬病原體和有毒碎片來實現的。最近的遺傳學研究一直強調小膠質細胞在阿爾茨海默病(AD)和其他神經退行性疾病發展中的作用,表明它們可以異常地開始吞噬突觸,神經元之間的關鍵連接。現在,倫敦大學學院(UCL)英國癡呆癥研究所的研究人員進行了一項研究,旨在更好地了解小膠質細胞可以增加患AD風險的吞噬過程。[查看]
http://m.baichuan365.com/Article/naturezkxgzwxbyfaech_1.html
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Palladium 5% HCl (v/v) 1000ug/mL
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 10,000ug/mL in 5% HCl
Palladium 10,000ug/mL in 5% HCl
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade II
D-乳酸脫氫酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮標準品
DADK嗪草酮標準品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化鋁 (Reduction Grade) 標準物質
氧化鋁 (Reduction Grade) 標準物質
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain