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Science子刊:利用智能手機超靈敏定量檢測唾液中的新冠病毒
根據一項新的研究,一種基于唾液的便攜式智能手機平臺為COVID-19測試提供了一種超靈敏但易于使用的方法,它可以在15分鐘內給出測試結果,而無需進行當前金標準所需的資源密集型實驗室測試。該方法在12名COVID-19感染者和6名健康對照者中進行了測試。相關研究結果于2020年12月11日在線發表在Science Advances期刊上,論文標題為“A smartphone-read ultrasensitive and quantitative saliva test for COVID-19”。論文通訊作者為美國杜蘭大學醫學院的Tony Y. Hu博士。[查看]
http://m.baichuan365.com/Article/sciencezklyznsjclmdl_1.html
Science子刊:環氧水解酶抑制劑可降低神經炎癥,有望治療阿爾茨海默病
神經炎癥與阿爾茨海默病(Alzheimer’s disease, AD)密切相關。越來越多的人已認識到神經炎癥在AD起著關鍵作用。環氧脂肪酸(epoxy fatty acid, EpFA)是花生四烯酸代謝途徑的衍生物,具有抗炎活性。然而,由于EpFA被可溶性環氧水解酶(soluble epoxide hydrolase, sEH)快速水解,它們的功效受到限制。在一項新的研究中,來自美國貝勒醫學院的研究人員報道sEH主要在星形膠質細胞中表達,并在AD患者的死后大腦組織和5xFAD β淀粉樣蛋白AD小鼠模型中升高。這種AD小鼠模型大腦中表達的sEH數量與大腦EpFA濃度下降有關。[查看]
http://m.baichuan365.com/Article/sciencezkhysjmyzjkjd_1.html
Nature子刊解讀!科學家們開發出能高效檢測人類脂肪肝和肝纖維化新型探測器!
大約25%的美國人都會患上脂肪肝,這種疾病會導致肝臟纖維化, 最終會導致肝功能衰竭;目前并沒有簡便的方法來診斷脂肪肝或肝纖維化,近日,一篇發表在國際雜志Nature Biomedical Engineering上題為“A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis”的研究報告中,來自麻省理工學院等機構的科學家們通過研究基于核磁共振技術(NMR)開發出了一種新型診斷工具,其或能用來診斷上述兩種肝臟疾病。[查看]
http://m.baichuan365.com/Article/naturezkjdkxjmkfcngx_1.html
Science解讀!揭秘輪狀病毒誘發嚴重胃腸道疾病的分子機制!
這篇研究報告中,研究人員發現,輪狀病毒感染的細胞能釋放名為二磷酸腺苷(ADP,adenosine diphosphate)的信號分子,該信號分子能與鄰近細胞上的細胞受體P2Y1相結合,ADP對P2Y1的激活就會導致未感染的細胞中產生名為細胞間鈣質波的信號分子,通過干擾ADP與其受體的結合就能夠降低小鼠疾病模型的腹瀉嚴重性,這就表明,靶向作用P2Y1或能作為一種有效的策略來控制人群中的病毒性腹瀉。[查看]
http://m.baichuan365.com/Article/sciencejdjmlzbdyfyzw_1.html
Science子刊解讀!空氣污染真會讓COVID-19的流行變得更加致命嗎?
近日,一篇刊登在國際雜志Science Advances上題為“Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis”的研究報告中,來自哈佛大學陳曾熙公共衛生學院等機構的科學家們通過研究發現,長期暴露于空氣污染物中的人群或許更易死于COVID-19。在對美國超過3000個縣的分析中,研究人員發現,長期暴露于細小顆粒物(PM2.5)的暴露量只要發生小幅增加,人群死于COVID-19的風險就會增加10%以上。[查看]
http://m.baichuan365.com/Article/sciencezkjdkqwrzhrco_1.html
Nature:外泌體能夠抵御細菌毒素,對抗超級細菌感染
近日,來自紐約大學朗格尼健康中心的Victor J. Torres和Ken Cadwell教授合作在Nature發表了題為“Decoy exosomes provide protection against bacterial toxins”的研究論文,該研究揭示了ATG蛋白能夠促進外泌體的釋放,進而在體外結合多種病原毒素,協助宿主抵御病原菌的感染。[查看]
http://m.baichuan365.com/Article/naturewmtngdyxjdsdkc_1.html
Radiology: Artificial Intelligence:人工智能幫助提高乳腺癌診斷率
根據《Radiology: Artificial Intelligence》雜志上發表的一項研究,人工智能(AI)可以提高放射科醫生在分析乳腺癌篩查乳房X光照片時的效率。[查看]
http://m.baichuan365.com/Article/radiologyartificiali_1.html
PNAS:PNAS解讀!科學家們有望利用一種新型的聚糖標記策略來揭秘肝臟中的免疫激活機制!
近日,一篇發表在國際雜志Proceedings of the National Academy of Sciences上題為“Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling”的研究報告中,來自斯克里普斯研究所等機構的科學家們通過研究提出了一種新型策略來捕獲聚糖分子和人類肝臟細胞中特殊蛋白激活子之間的相互作用,這樣一來,研究人員就能應用新技術來理解肝臟疾病的發生機制和機體的免疫激活機制。[查看]
http://m.baichuan365.com/Article/pnaspnasjdkxjmywlyyz_1.html
BMJ子刊解讀!多喝綠茶和咖啡或能明顯降低2型糖尿病患者的全因死亡風險 最高可達63%!
近日,一篇發表在國際雜志BMJ Open Diabetes Research & Care上題為“Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry”的研究報告中,來自日本九州大學等機構的科學家們通過研究發現,攝入大量綠茶和咖啡或與2型糖尿病患者全因死亡風險降低直接相關。[查看]
http://m.baichuan365.com/Article/bmjzkjddhlchkfhnmxjd_1.html
高純度EIA診斷開發專用 辣根過氧化物酶 CAS:9003-99-0
辣根過氧化物酶(Horseradish Peroxidase, HRP, CAS#9003-99-0),來源于辣根,在臨床檢驗中有廣泛的作用。既可以用作生化反應中的指示劑,也可以用作免疫反應(尤其是ELISA)中標記試劑,是酶標抗體的關鍵原料。辣根過氧化物酶作為多個試劑盒顯色體系的關鍵成分,對試劑盒的質量有重要影響。西寶生物提供優質的辣根過氧化物酶(HRP),純度高,穩定性好,咨詢熱線400-021-8158。[查看]
http://m.baichuan365.com/Article/lggyhwm_1.html
Fluorospark(R) 激酶/<font color='red'>AD</font>P 多重檢測試劑盒(291-77401)
Fluorospark(R) 激酶/ADP 多重檢測試劑盒(291-77401)Fluorospark(R) Kinase/ADP Multi-Assay Kit是和光(wako)與日本東京大學新藥研究機構共同研發的ADP熒光檢測試劑盒。擁有高通量篩選(HTS)必備的高靈敏度、高準確度、低成本、簡便等特性。本產品不僅可檢測激酶,同時可用于檢測產生ADP的酶(如ATP酶、乙酰基—CoA羧化酶)的活性[查看]
http://m.baichuan365.com/Article/291-77401_1.html
Nature:開發出一種適應小鼠的SARS-CoV-2模型,為測試一系列藥物和疫苗奠定基礎
在一項新的研究中,來自美國北卡羅來納大學教堂山分校等研究機構的研究人員開發出的一種新的COVID-19小鼠模型重現了這種人類疾病的許多特征,并有助于推動COVID-19候選疫苗進入臨床試驗。相關研究結果于2020年8月27日在線發表在Nature期刊上,論文標題為“A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures”。[查看]
http://m.baichuan365.com/Article/naturekfcyzsyxsdsars_1.html
進口 高品質 抗地高辛抗體(anti-digoxin antibody,<font color='red'>AD</font>A)
抗地高辛抗體(anti-digoxin antibody,ADA)。 地高辛(Digoxin)是一種從洋地黃提取出的beta抑制劑性的藥物。由于地高辛的治療指數狹窄,用藥過量與用藥不足時的癥狀相似,加之其個體差異大,故中毒的發生率高,是臨床上難掌握藥物。目前解除地高辛毒性的有效的方法是應用由地高辛抗體。此外,采用抗地高辛抗體的免疫分析法監測血清/血漿地高辛濃度已成為當今治療性藥物監測的典范。[查看]
http://m.baichuan365.com/Article/jkgpzkdgxktantidigox_1.html
科學家發現口服小劑量代謝化合物可恢復小鼠生育能力
近日,發表在發表在Cell Reports上的一項研究中,研究人員使用小劑量能逆轉卵子衰老過程的代謝化合物,成功提升了老年雌性小鼠的生育率,這為一些受孕困難的婦女帶來了希望。該研究提到的分子和“前體”的名字分別為NAD(煙酰胺腺嘌呤二核苷酸)和NMN(煙酰胺單核苷酸)。[查看]
http://m.baichuan365.com/Article/kxjfxkfxjldxhhwkhfxs_1.html
研究揭示小鼠基態多能干細胞的轉錄調控新機制
近日,中國科學院廣州生物醫藥與健康研究院Miguel A. Esteban實驗室和以色列魏茨曼科學研究院Jacob H. Hanna實驗室及武漢大學陳亮實驗室的研究人員合作在Science Advances在線發表了研究成果。該研究發現在基態多能干細胞中,激活的β-catenin通過在多能性位點招募輔調控因子促進多能性基因的轉錄起始,減少了對BRD4/CDK9調控的暫停釋放的依賴,但是對抑制轉錄起始更敏感,從而解釋了基態多能干細胞在面臨外界擾動時更穩定的原因。[查看]
http://m.baichuan365.com/Article/multifuctionalstemcell_1.html
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Gadolinium 2-5% HNO3 1,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 1,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 1,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 10,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 10,000ug/mL
Gadolinium 2-5% HNO3 10,000ug/mL
Gadolinium 2-5% HNO3 10,000ug/mL
Lead 2-5% HNO3 100ug/mL
Lead 2-5% HNO3 100ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 1000ppm in 2% HNO3
Lead 1000ppm in 2% HNO3
Lead 2 - 5% HNO3 (v/v) 10,000ug/mL
Lead 2 - 5% HNO3 (v/v) 10,000ug/mL
Palladium 100ppm in 5% HCl
Palladium 100ppm in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 10,000ug/mL in 5% HCl
Palladium 10,000ug/mL in 5% HCl
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade II
D-乳酸脫氫酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮標準品
DADK嗪草酮標準品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化鋁 (Reduction Grade) 標準物質
氧化鋁 (Reduction Grade) 標準物質
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain