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研究揭示小鼠基態(tài)多能干細(xì)胞的轉(zhuǎn)錄調(diào)控新機(jī)制
近日,中國科學(xué)院廣州生物醫(yī)藥與健康研究院Miguel A. Esteban實驗室和以色列魏茨曼科學(xué)研究院Jacob H. Hanna實驗室及武漢大學(xué)陳亮實驗室的研究人員合作在Science Advances在線發(fā)表了研究成果。該研究發(fā)現(xiàn)在基態(tài)多能干細(xì)胞中,激活的β-catenin通過在多能性位點招募輔調(diào)控因子促進(jìn)多能性基因的轉(zhuǎn)錄起始,減少了對BRD4/CDK9調(diào)控的暫停釋放的依賴,但是對抑制轉(zhuǎn)錄起始更敏感,從而解釋了基態(tài)多能干細(xì)胞在面臨外界擾動時更穩(wěn)定的原因。[查看]
http://m.baichuan365.com/Article/multifuctionalstemcell_1.html
WAKO  Vitamin B1 B2定量測定用 酸性磷酸酶
016-24901 酸性磷酸酶 是由米曲霉(Aspergillus oryzae)產(chǎn)生的一種純化酶、含有多種酶。測定維生素B1、B2時,利用高磷酸酶的活性,可將其從結(jié)合形式分解為游離形式。016-24901 酸性磷酸酶和通常測定維生素B1?B2時使用的TakadiastaseU高峰淀粉酶U(通常用于定量維生素B1和B2)的酶相同,可以一樣使用。咨詢訂購熱線:400-021-8158[查看]
http://m.baichuan365.com/Article/wakovitaminb1b2dlcdy_1.html
阿爾茨海默癥 <font color='red'>AD</font> 研究用 - 分泌酶抑制劑
β-淀粉樣蛋白(Aβ)是阿爾茨海默病主要病理特征——老人斑的主要構(gòu)成成分,是通過β分泌酶和γ分泌酶切斷β-淀粉樣蛋白前體蛋白質(zhì)(APP)而產(chǎn)生的。因此,分泌酶抑制劑可作為β-淀粉樣蛋白產(chǎn)生抑制劑進(jìn)行研究。[查看]
http://m.baichuan365.com/Article/aezhmzyjyfmmyzj_1.html
Sci Adv:弱毒性瘧疾疫苗初步效果良好
在一項創(chuàng)新研究中,Radboudumc和LUM??C聯(lián)合測試了一種弱毒性的瘧疾候選疫苗。該臨床試驗的結(jié)果發(fā)表在《Science Translational Medicine》雜志上,表明該疫苗是安全的,并且可引發(fā)針對瘧疾感染的防御反應(yīng)。[查看]
http://m.baichuan365.com/Article/sciadvrdxnjymcbxglh_1.html
PNAS:揭示SARS-CoV-2高傳染性和隱蔽性的原因!
導(dǎo)致COVID-19的SARS-CoV-2病毒具有高度傳染性。奇怪的是,在許多病人中,它會引起較差的免疫反應(yīng),從而延長疾病的時間。這有助于病毒的廣泛傳播,加劇了全球大流行。在發(fā)表在Proceedings of the National Academy of Sciences雜志上的一項新研究中,明尼蘇達(dá)大學(xué)的研究人員發(fā)現(xiàn)了一種生物化學(xué)機(jī)制,這種機(jī)制或許可以解釋這種病毒如何在有效感染人類的同時逃避免疫反應(yīng)。[查看]
http://m.baichuan365.com/Article/pnasjssarscov2gcrxhy_1.html
Lancet Infect Dis:MERS冠狀病毒疫苗有望治療MERS
近日,研究人員發(fā)現(xiàn)一種中東呼吸綜合征冠狀病毒疫苗在人體試驗中展現(xiàn)出療效,這可能有助于開發(fā)一種針對新型病毒的疫苗。該研究通訊作者、德國Hamburg-Eppendorf大學(xué)醫(yī)學(xué)中心傳染病部門負(fù)責(zé)人、DZIF科學(xué)家Marylyn Addo教授解釋說:"疫苗試驗的結(jié)果對于開發(fā)一種針對新型冠狀病毒SARS-CoV-2的疫苗很重要,也讓我們充滿希望。中東呼吸綜合征疫苗的開發(fā)為我們在DZIF快速開發(fā)針對新型冠狀病毒的疫苗提供了基礎(chǔ)。"[查看]
http://m.baichuan365.com/Article/lancetinfectdismersg_1.html
Nat Med:迄今為止最大規(guī)模的蛋白質(zhì)組學(xué)研究揭示葡萄糖代謝蛋白與阿爾茲海默病之間的神秘關(guān)聯(lián)!
如今我們對阿爾茲海默病的病理生理學(xué)機(jī)制了解地仍然并不完全,近日,一篇發(fā)表在國際雜志Nature Medicine上題為“Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation”的研究報告中,來自埃默里大學(xué)醫(yī)學(xué)院等機(jī)構(gòu)的科學(xué)家們就通過利用定量質(zhì)譜法和共表達(dá)網(wǎng)絡(luò)分析技術(shù)進(jìn)行了迄今為止最大規(guī)模的蛋白質(zhì)組學(xué)研究將機(jī)體的葡萄糖代謝蛋白與阿爾茲海默病(AD)疾病生物學(xué)特性聯(lián)系了起來。[查看]
http://m.baichuan365.com/Article/natmedqjwzzdgmddbzzx_1.html
Cancer Res:胰腺癌細(xì)胞或會分泌特殊信號來阻斷機(jī)體對腫瘤的免疫攻擊
近日,一篇發(fā)表在國際雜志Cancer Research上的研究報告中,來自紐約大學(xué)等機(jī)構(gòu)的科學(xué)家們通過研究發(fā)現(xiàn),一種關(guān)鍵的免疫信號或在關(guān)閉免疫系統(tǒng)攻擊胰腺癌上扮演著此前未知的角色,文章中,研究人員發(fā)現(xiàn),免疫信號蛋白—白細(xì)胞介素1β(IL-1β)能被胰腺腫瘤細(xì)胞制造并釋放,同時其會降低機(jī)體的抗癌免疫反應(yīng),從而促進(jìn)胰腺導(dǎo)管腺癌(PDA,pancreatic ductal adenocarcinoma)的生長,PDA是一種通常會在兩年內(nèi)致命的癌癥類型。[查看]
http://m.baichuan365.com/Article/cancerresyxaxbhhfmts_1.html
Nature子刊:開發(fā)安全且有一定療效的HIV疫苗
近日來自美國亨利·杰克遜軍事醫(yī)學(xué)發(fā)展基金會和沃爾特·里德陸軍研究所美國軍方艾滋病毒研究項目組的研究人員在Nature Medicine上發(fā)表了一篇題為"Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption"的文章。[查看]
http://m.baichuan365.com/Article/naturezkkfaqqyydlxdh_1.html
BAFF,APRIL生物標(biāo)志物-自身免疫性疾病系列專題
西寶生物作為一家生命科學(xué)領(lǐng)域的綜合服務(wù)商,可提供自身免疫疾病研究整體解決方案包括BAFF(B細(xì)胞活化因子),APRIL(增殖誘導(dǎo)配體)重組蛋白、抗體、ELISA試劑盒、CD40特異性抗體(AdipoGen)和CD40L高活性蛋白(Miragen),咨詢熱線:400-021-8158[查看]
http://m.baichuan365.com/Article/baffaprilzsmyxjbxlzt_1.html
Science子刊:揭示癌細(xì)胞多藥耐藥的新機(jī)制
韓國科學(xué)技術(shù)研究院(KAIST)的研究人員已經(jīng)確定了對一線化療的獲得性耐藥轉(zhuǎn)移到二線靶向治療的機(jī)制,這種機(jī)制導(dǎo)致了癌癥耐藥的"多米諾效應(yīng)"。他們的研究發(fā)表在近日的《Science Advances》上,該研究提出了一種新策略,用于改善對抗癌藥物產(chǎn)生耐藥性的患者的癌癥治療的二線療法。[查看]
http://m.baichuan365.com/Article/sciencezkjsaxbdynydx_1.html
Nature Genetics: <font color='red'>AD</font>AMTS19缺失導(dǎo)致進(jìn)行性非綜合征性心臟瓣膜病
近日,加拿大蒙特利爾大學(xué)等科研機(jī)構(gòu)的研究人員在Nature Genetics上發(fā)表了題為“Loss of ADAMTS19 causes progressive non-syndromic heart valve disease”的文章,發(fā)現(xiàn)ADAMTS19缺失導(dǎo)致進(jìn)行性非綜合征性心臟瓣膜病。[查看]
http://m.baichuan365.com/Article/naturegeneticsadamts_1.html
PNAS:科學(xué)家有望開發(fā)出治療艱難梭菌感染的新型藥物療法
近日,一項刊登在國際雜志Proceedings of the National Academy of Sciences上的研究報告中,來自紐約市立大學(xué)等機(jī)構(gòu)的科學(xué)家們通過研究或有望幫助開發(fā)治療艱難梭菌(clostridium difficile)感染的新藥,艱難梭菌會引發(fā)腹瀉、惡心、內(nèi)出血和潛在死亡,其對公眾健康會帶來嚴(yán)重威脅,每年在美國這種細(xì)菌都會感染大約50萬人,而且會造成1.5萬人死亡。[查看]
http://m.baichuan365.com/Article/pnaskxjywkfczljnsjgr_1.html
阿爾茨海默癥與β淀粉樣蛋白的前生今世
阿爾茨海默癥(Alzheimer disease;AD)患者的大腦中,老人斑是顯著的病理特征之一,是不溶性蛋白質(zhì)異常聚集形成豐富的β片層結(jié)構(gòu)的淀粉樣纖維,并積累于腦實質(zhì)細(xì)胞間隙的構(gòu)成物。老人斑被認(rèn)為是AD發(fā)病過程中的早期病變。1985年Masters等人開始研究老人斑淀粉樣蛋白,對其進(jìn)行分離純化和氨基酸測定,證實老人斑的主要構(gòu)成成分為β-淀粉樣蛋白多肽(Aβ)。[查看]
http://m.baichuan365.com/Article/aechmzydfydbdqsjs_1.html
Mol Cancer Res:鑒別出關(guān)鍵靶點有望開發(fā)出治療三陰性乳腺癌的新型療法
日前,一項刊登在國際雜志Molecular Cancer Research上的研究報告中,來自Lady Davis研究所的科學(xué)家們通過研究鑒別出了一種特殊蛋白,其在惡性乳腺癌對化療產(chǎn)生耐藥的過程中扮演著非常關(guān)鍵的角色,相關(guān)研究結(jié)果有望幫助開發(fā)克服乳腺癌藥物耐受性的新型策略。[查看]
http://m.baichuan365.com/Article/molcancerresjbcgjbdy_1.html
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Vanadium Standard 10000ppm in 0.5M HNO3
Vanadium Standard 10000ppm in 0.5M HNO3
Cadmium 2-5% HNO3 100ug/mL
Cadmium 2-5% HNO3 100ug/mL
Cadmium 2-5% HNO3 1,000ug/mL
Cadmium 2-5% HNO3 1,000ug/mL
Cadmium 2% HCl 1,000ug/mL
Cadmium 2% HCl 1,000ug/mL
Cadmium 2-5% HNO3 1,000ug/mL
Cadmium 2-5% HNO3 1,000ug/mL
Cadmium 2-5% HCl 1,000ug/mL
Cadmium 2-5% HCl 1,000ug/mL
Cadmium 2-5% HNO3 1,000ug/mL
Cadmium 2-5% HNO3 1,000ug/mL
Cadmium 2% HCl (v/v) 1,000ug/mL
Cadmium 2% HCl (v/v) 1,000ug/mL
Cadmium 2-5% HNO3 (v/v) 10,000ug/mL
Cadmium 2-5% HNO3 (v/v) 10,000ug/mL
Cadmium 2-5% HNO3 10,000ug/mL
Cadmium 2-5% HNO3 10,000ug/mL
Cadmium 2-5% HCl 10,000ug/mL
Cadmium 2-5% HCl 10,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 100ug/mL
Gadolinium 2-5% HNO3 (v/v) 100ug/mL
Gadolinium 2-5% HNO3 1,000ug/mL
Gadolinium 2-5% HNO3 1,000ug/mL
Gadolinium 2-5% HNO3 1,000ug/mL
Gadolinium 2-5% HNO3 1,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 1,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 1,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 10,000ug/mL
Gadolinium 2-5% HNO3 (v/v) 10,000ug/mL
Gadolinium 2-5% HNO3 10,000ug/mL
Gadolinium 2-5% HNO3 10,000ug/mL
Lead 2-5% HNO3 100ug/mL
Lead 2-5% HNO3 100ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 2-5% HNO3 1,000ug/mL
Lead 1000ppm in 2% HNO3
Lead 1000ppm in 2% HNO3
Lead 2 - 5% HNO3 (v/v) 10,000ug/mL
Lead 2 - 5% HNO3 (v/v) 10,000ug/mL
Palladium 100ppm in 5% HCl
Palladium 100ppm in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 10,000ug/mL in 5% HCl
Palladium 10,000ug/mL in 5% HCl
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade II
D-乳酸脫氫酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮標(biāo)準(zhǔn)品
DADK嗪草酮標(biāo)準(zhǔn)品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化鋁 (Reduction Grade) 標(biāo)準(zhǔn)物質(zhì)
氧化鋁 (Reduction Grade) 標(biāo)準(zhǔn)物質(zhì)
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain