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加州大學(xué)洛杉磯分校(UCLA)的科學(xué)家們發(fā)現(xiàn)了一種治療膠質(zhì)母細(xì)胞瘤(最致命的腦癌類(lèi)型)的潛在新策略,即通過(guò)重新編程將具有侵略性的癌細(xì)胞轉(zhuǎn)變?yōu)闊o(wú)害的細(xì)胞。相關(guān)研究結(jié)果發(fā)表在《美國(guó)國(guó)家科學(xué)院院刊》上,研究表明,將放療與一種名為福斯可林的植物衍生化合物相結(jié)合,可以迫使膠質(zhì)母細(xì)胞瘤細(xì)胞進(jìn)入休眠狀態(tài),使其無(wú)法分裂或擴(kuò)散。[查看]
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http://m.baichuan365.com/Article/pnasjqxxaxbzxbcwwhda_1.html
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日本東京科學(xué)研究所Takanori Takebe教授領(lǐng)導(dǎo)的研究小組研究了不同類(lèi)型干細(xì)胞之間mRNA轉(zhuǎn)移的機(jī)制和作用。他們的研究結(jié)果發(fā)表在2025年1月22日的《美國(guó)國(guó)家科學(xué)院院刊》。[查看]
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http://m.baichuan365.com/Article/pnasxbjmrnazygbrldng_1.html
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研究人員在國(guó)際知名期刊《Nature Biomedical Engineering》上發(fā)表了一篇題為“Small circular RNAs as vaccines for cancer immunotherapy”的論文。該研究在癌癥免疫治療領(lǐng)域取得了突破性進(jìn)展,為開(kāi)發(fā)新型癌癥疫苗提供了重要的理論依據(jù)和技術(shù)支持。這一成果不僅展示了小環(huán)狀RNA(circRNA)在癌癥治療中的巨大潛力,還為未來(lái)癌癥疫苗的研發(fā)提供了新的思路和方向[查看]
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http://m.baichuan365.com/Article/nbexhzrnaymazmyzldxs_1.html
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發(fā)表在《Cell》雜志上的一篇文章中,科學(xué)家們把注意力集中在一種小核核RNAs (snoRNAs)上,這種RNA通過(guò)抑制核糖體的產(chǎn)生而使細(xì)胞停止分裂除了擴(kuò)大科學(xué)家對(duì)這類(lèi)生物分子在細(xì)胞衰老中的作用的了解之外,這些發(fā)現(xiàn)還可以為設(shè)計(jì)新的核糖體疾病治療方法提供信息。[查看]
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http://m.baichuan365.com/Article/cellyzsmallrnayqlnzs_1.html
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圣詹姆斯醫(yī)院都柏林三一學(xué)院的研究人員對(duì)一種以前基本上不為人知的、但至關(guān)重要的“自然殺手”(NK)免疫細(xì)胞的行為和代謝功能提供了重要的見(jiàn)解。他們的研究結(jié)果發(fā)表在今天(2024年10月10日星期四)的《美國(guó)國(guó)家科學(xué)院院刊》(PNAS)上,為進(jìn)一步探索NK細(xì)胞為一系列肺部疾病(包括慢性阻塞性肺疾病(COPD)、癌癥和結(jié)核病)的未來(lái)治療和療法的發(fā)展奠定了基礎(chǔ)。[查看]
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http://m.baichuan365.com/Article/20241016_inustrialnews_1.html
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麥克馬斯特大學(xué)的研究人員發(fā)現(xiàn),亨廷頓舞蹈癥患者體內(nèi)突變的蛋白質(zhì)不能像預(yù)期的那樣修復(fù)DNA,從而影響了腦細(xì)胞自愈的能力。這項(xiàng)研究于2024年9月27日發(fā)表在美國(guó)國(guó)家科學(xué)院院刊上,發(fā)現(xiàn)亨廷頓蛋白有助于產(chǎn)生對(duì)修復(fù)DNA損傷很重要的特殊分子。這些分子被稱(chēng)為Poly [ADP-ribose],聚集在受損的DNA周?chē)褚粡埦W(wǎng)一樣,吸引修復(fù)過(guò)程所需的所有因素。[查看]
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http://m.baichuan365.com/Article/pnasyqxddnaxfjzyhtds_1.html
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希伯來(lái)大學(xué)的Yosef Buganim教授和Howard Cedar教授以及賓夕法尼亞大學(xué)的Ben Stanger教授領(lǐng)導(dǎo)的一項(xiàng)新研究發(fā)表在《美國(guó)國(guó)家科學(xué)院院刊》上,該研究為將一種特化細(xì)胞轉(zhuǎn)化為另一種特化細(xì)胞的挑戰(zhàn)提供了新的視角,這是再生醫(yī)學(xué)進(jìn)步的關(guān)鍵過(guò)程。盡管最近取得了進(jìn)展,但研究人員發(fā)現(xiàn),維持重編程細(xì)胞新身份的一個(gè)關(guān)鍵障礙在于它們?cè)瓉?lái)的DNA甲基化模式——這是定義細(xì)胞身份的關(guān)鍵標(biāo)記。[查看]
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http://m.baichuan365.com/Article/pnasxbzzbcgcznywqgbs_1.html
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核糖核酸(RNA)是一種在生物遺傳學(xué)中具有重要功能的生物分子,在生命的起源和進(jìn)化中起著關(guān)鍵作用。RNA的組成與DNA非常相似,它能夠執(zhí)行各種生物功能,這取決于它的空間構(gòu)象,即分子在自身上折疊的方式。現(xiàn)在,發(fā)表在《美國(guó)國(guó)家科學(xué)院院刊》(PNAS)上的一篇論文首次描述了RNA在低溫下折疊的過(guò)程如何為研究地球上的原始生物化學(xué)和生命進(jìn)化開(kāi)辟了一個(gè)新的視角。[查看]
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http://m.baichuan365.com/Article/pnastcxsjdwxrnadxswh_1.html
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我們的身體有一個(gè)質(zhì)量控制系統(tǒng),可以識(shí)別錯(cuò)誤折疊的蛋白質(zhì),并將它們標(biāo)記為額外的折疊工作或破壞,但是,這個(gè)質(zhì)量控制過(guò)程究竟是如何起作用的,我們還不完全清楚。馬薩諸塞大學(xué)阿姆赫斯特分校(University of Massachusetts Amherst)的研究人員發(fā)現(xiàn)了所有行為發(fā)生的“熱點(diǎn)”,在我們對(duì)這種質(zhì)量控制系統(tǒng)如何工作的理解上取得了重大飛躍。這項(xiàng)研究最近發(fā)表在《PNAS》上。[查看]
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http://m.baichuan365.com/Article/pnasalphafold2zljsxb_1.html
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科隆大學(xué)的研究人員揭示了一種保護(hù)胰腺β細(xì)胞的機(jī)制,這種細(xì)胞對(duì)胰島素的產(chǎn)生至關(guān)重要,可以防止炎癥細(xì)胞死亡。本研究探討受體相互作用蛋白激酶1 (receptor-interacting protein kinase 1, RIPK1)在調(diào)節(jié)β細(xì)胞存活中的作用。[查看]
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http://m.baichuan365.com/Article/cellzkdtdjzbhyxxbmsy_1.html
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摘要:根據(jù)發(fā)表在PNAS上的一篇文章,不產(chǎn)生白細(xì)胞介素22結(jié)合蛋白(IL-22BP)的小鼠具有更強(qiáng)的防御能力。
發(fā)表在《美國(guó)國(guó)家科學(xué)院院刊》(PNAS)上的一項(xiàng)研究表明,一種名為IL-22BP的特定蛋白質(zhì)的存在如何影響腸道微生物群的組成和身體對(duì)細(xì)菌感染的反應(yīng)。
“我們發(fā)現(xiàn),不產(chǎn)生這種蛋白質(zhì)的小鼠更能抵御艱難梭狀芽孢桿菌和嚙齒檸檬酸桿菌等細(xì)菌的腸道感染,”該文章的合著者M(jìn)arco aur lio Ramirez Vinolo告訴記者。他是巴西坎皮納斯州立大學(xué)生物研究所(IB-UNIC[查看]
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http://m.baichuan365.com/Article/pnasyxcdwswqjkhdxjgr_1.html
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VLVbio,專(zhuān)注于研究檢測(cè)細(xì)胞死亡方式(凋亡或壞死),可提供M30 Apoptosense? ELISA試劑盒和M65 EpiDeath? ELISA試劑盒,廣泛用于非酒精性脂肪性肝炎(NASH) 的研究和藥物開(kāi)發(fā)領(lǐng)域。[查看]
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http://m.baichuan365.com/Article/VLVbio_1.html
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M30 Apoptosense(R) ELISA可檢測(cè) K18 片段的濃度,是檢測(cè)和篩查 NASH 的可靠的特異性工具。最近的兩項(xiàng)薈萃分析表明,K18 片段的水平可以預(yù)測(cè) NASH 的存在,其 pooled AUROC 值為 0.82、伴隨 78% 的靈敏度和 86% 的特異性;AUROC 值為 0.8445、伴隨 83% 的靈敏度和 71% 的特異性。[查看]
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http://m.baichuan365.com/Article/M30_1.html
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了解核受體如何參與非酒精性脂肪性肝病(NAFLD)或非酒精性脂肪性肝炎(NASH)的發(fā)病機(jī)制,可能為肝病新療法的研發(fā)提供新的方向。在藥物和治療發(fā)現(xiàn)中,最常見(jiàn)的核受體是由配體激活的核受體,包括過(guò)氧化物酶體增殖物激活受體α(PPARα)、孕烷X受體(PXR)和組成型雄甾烷受體(CAR),它們是最早被確定的化學(xué)毒物反應(yīng)的關(guān)鍵調(diào)節(jié)受體。使用小鼠疾病模型和人體樣本的大量研究表明,這些受體和PPARβ/δ、PPARγ、法尼醇X受體(FXR)和肝X受體(LXR)等其他受體,通過(guò)調(diào)節(jié)腸-肝-脂肪軸在維持營(yíng)養(yǎng)/能量穩(wěn)態(tài)方面發(fā)揮著關(guān)鍵作用。[查看]
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http://m.baichuan365.com/Article/NASH_1.html
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近日,一項(xiàng)發(fā)表在《美國(guó)國(guó)家科學(xué)院院刊》(PNAS)上的研究分析了大腸桿菌(E. coli)如何在幾乎無(wú)菌的新鮮尿液中利用宿主的營(yíng)養(yǎng)物質(zhì)快速繁殖。[查看]
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http://m.baichuan365.com/Article/pnasdcgjrhzcnlgr_1.html
記錄總數(shù):299 | 頁(yè)數(shù):20 <...10111213141516171819...>
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測(cè)序級(jí)谷氨酰蛋白內(nèi)切酶 Endoproteinase Glu-C
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Neutrophil gelatinase-associated lipocalin (NGAL)
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Neutrophil gelatinase-associated lipocalin (NGAL)
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鼠源RNase抑制劑
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測(cè)序級(jí)天冬氨酰蛋白內(nèi)切酶 Endoproteinase Asp-N
-

-
BANASS-Brilliant Yellow Methanol (90) Solution
-

-
Methanol, Luminasol(R)
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Dimethyl Sulfoxide, Luminasol(R)
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-
Acetonitrile, Luminasol(R)
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-
Alkalophilic proteinase
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Creatinine deiminase
-

-
D-Fructose dehydrogenase
-

-
Formaldehyde dehydrogenase
-

-
Glycerol-3-phosphate dehydrogenase
-

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Glucose-6-phosphate dehydrogenase
-

-
Glucose-6-phosphate dehydrogenase
-

-
Glucose dehydrogenase (NAD(P)-dependent)
-

-
Glucose dehydrogenase (PQQ-dependent)
-

-
Glutamate dehydrogenase(NADP dependent)
-

-
Glutamate dehydrogenase (NAD dependent)
-

-
Glutamate dehydrogenase (NADP dependent)
-

-
Glycerol dehydrogenase
-

-
Glycerol kinase
-

-
Glycerol kinase
-

-
D-3-Hydroxybutyrate dehydrogenase
-

-
Hexokinase
-

-
Lactate dehydrogenase
-

-
D-Lactate dehydrogenase
-

-
Leucine dehydrogenase
-

-
Malate dehydrogenase
-

-
Protocatechuate 3,4-dioxygenase
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-
1,5-Anhydroglucitol-6-phosphate Dehydrogenase
-

-
3-alpha-Hydroxysteroid Dehydrogenase
-

-
12α-Hydroxysteroid Dehydrogenase
-

-
3-Hydroxybutyrate Dehydrogenase
-

-
ADP-dependent Hexokinase
-

-
ADP-dependent Hexokinase
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-
Glucose-6-phosphate Dehydrogenase
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-
Glycerol Kinase
-

-
Hexokinase
-

-
Hexokinase
-

-
Phosphofructokinase
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-
Sphingomyelinase
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Xanthine Dehydrogenase
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-
Creatine Kinase
-

-
Lactate Dehydrogenase
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Adenosine Deaminase,from calf intestine, suspension
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Cholesterol Esterase,from Pseudomonas species, lyophilizate
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-
Cholesterol Esterase, chemically modified,from Pseudomonas species, lyophilizate
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Cholesterol Esterase,from Pseudomonas species, solution
-

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Creatinase,from microorganism, lyophilizate
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Creatininase,from microorganism, lyophilizate
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Creatinine Deaminase,from Corynebacterium lilium, lyophilizate
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Galactose 1-Dehydrogenase,from E.coli overproducer, lyophilizate
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Galactose 1-Dehydrogenase,from E.coli overproducer, suspension
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Galactose 1-Dehydrogenase,from Pseudomonas fluorescens, suspension
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Glucose-6-phosphate Dehydrogenase (G6P-DH),rom Leuconostoc mesenteroides, expressed in E. coli,lyophilizate
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Glucose-6-phosphate Dehydrogenase(G6P-DH), chemically modified,from Leuconostoc mesenteroides, expressed in E. coli,lyophilizate
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Glucose-6-phosphate Dehydrogenase(G6P-DH),from Leuconostoc mesenteroides, expressed in E. coli,solution
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Glucose-6-phosphate Dehydrogenase(G6P-DH),from Leuconostoc mesenteroides, lyophilizate
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Glucose-6-phosphate Dehydrogenase(G6P-DH),from Leuconostoc mesenteroides, expressed in E. coli,reduced phosphate, lyophilizate
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-
Glucose-6-phosphate Dehydrogenase(G6P-DH),from Leuconostoc mesenteroides, suspension
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Glucose-6-phosphate Dehydrogenase(G6P-DH),from yeast, lyophilizate
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Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
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Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
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Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
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Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
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-
Glycerol Kinase (GK),from Bacillus stearothermophilus, lyophilizate
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-
Glycerol Kinase (GK),from Bacillus stearothermophilus, solution
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-
Glycerol Kinase (GK), concentrated,from Bacillus stearothermophilus, solution
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Glycerol-3-phosphate Dehydrogenase,from rabbit muscle, suspension
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-
Hexokinase (HK),from yeast overproducer, lyophilizate
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-
Hexokinase (HK), chemically modified,from yeast overproducer, lyophilizate
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Hexokinase (HK),from yeast overproducer, solution
-

-
Hexokinase (HK),from yeast, lyophilizate
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-
L-Lactate Dehydrogenase (L-LDH),from pig muscle, for use of AST/GOT-Determination according to IFCC recommendations, lyophilizate
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L-Lactate Dehydrogenase (L-LDH), chemically modified,from pig muscle, for use of AST/GOT-Determination according to IFCC recommendations, solution
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L-Lactate Dehydrogenase (L-LDH),from pig muscle, suspension
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L-Lactate Dehydrogenase (L-LDH),chemically modified,from pig heart, lyophilizate
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-
L-Lactate Dehydrogenase (L-LDH),from pig heart, suspension
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L-Lactate Dehydrogenase (L-LDH)from rabbit muscle, suspension
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Lipoprotein Lipase,from Pseudomonas species, lyophilizate
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Lipoprotein Lipase, chemically modified,from Pseudomonas species, lyophilizate
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Malate Dehydrogenase,from pig heart, lyophilizate
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Malate Dehydrogenase, chemically modified,from pig heart, lyophilizate
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Malate Dehydrogenase, IFCC Quality,from pig heart, lyophilizate
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Malate Dehydrogenase, IFCC Quality,from pig heart, solution
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N-Methylhydantoinase (ATP-hydrolyzing),from Arthrobacter species, expressed in E. coli, lyophilizate
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NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
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Phosphogluconate Dehydrogenase (decarboxylating),from yeast, lyophilizate
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6-Phosphogluconolactonase,from Leuconostoc mesenteroides, lyophilizate
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Pyruvate Kinase,from Bacillus stearothermophilus, lyophilizate
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Pyruvate Kinase,from rabbit muscle, suspension
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Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
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Endoproteinase Glu-C,from Staphylococcus aureus V8, lyophilizate, salt-free
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Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
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Endoproteinase Lys-C,from Lysobacter enzymogenes, lyophilizate
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Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
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Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
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Pronase,from Streptomyces griseus, lyophilizate
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N-Acylmannosamine 1-dehydrogenase (NAMD-E)
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Creatinase (C2-AE)
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Creatinase (C2-AT)
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Creatininase (C1- E)
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L-Fucose dehydrogenase(FDH-E)*
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Glucose-6-phosphate dehydrogenase (GPD-M)
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Glutaminase (GLN)
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3alpha-Hydroxysteroid dehydrogenase (3aHSD-E)
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Lactate dehydrogenase (LDH-P)
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Lactate dehydrogenase (LDH-R)
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Malate dehydrogenase (MDH-P)
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Tannase (TAH)
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Cholesterol dehydrogenase
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Glucose-6-Phosphate Dehydrogenase
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Glycerol Kinase 6495.
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Hexokinase
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Lactate Dehydrogenase
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Lactate Dehydrogenase
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Malate Dehydrogenase 1521.
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Glucose Dehydrogenase (NAD Dependent)
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Glucose-6-Phosphate Dehydrogenase
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Hexokinase
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Proteinase K
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Glycerol Kinase Amano2
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Cholesterol Dehydrogenase Amano 5
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Glucose Dehydrogenase Amano 2
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Lactate Dehydrogenase Amano 3
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Malate Dehydrogenase Amano 3
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Penicillinase
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Penicillinase Bulk Powder
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Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
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Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
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Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
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Mab Mix creatinine kinase isoenzyme MM
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Creatine Kinase-MM Monoclonal Antibody (14.15)
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Creatine Kinase-MM Monoclonal Antibody (14.5)
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Creatine Kinase-MM Monoclonal Antibody (14.52)