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P<font color='red'>NAS</font>:新技術讓癌細胞更容易暴露出來
日本北海道大學和美國密蘇里大學等機構的研究人員開發出一種新技術,以增加癌細胞中MHC I類分子的數量。據介紹,這種新方法有望增強免疫系統檢測和消除癌細胞的能力。[查看]
http://m.baichuan365.com/Article/pnasxjsraxbgryblcl_1.html
《P<font color='red'>NAS</font>》一種不為人知的蛋白質,它能保持人體細胞的健康
圣保羅大學的研究人員與澳大利亞同事合作,發現了一種獨特的細菌蛋白,即使細胞有沉重的細菌負擔,也能保持人體細胞的健康。這一突破為開發與線粒體功能障礙相關的各種疾病(包括癌癥和自身免疫性疾病)的新療法提供了潛力。線粒體是細胞的“發電站”,對提供細胞生化反應所需的能量至關重要。[查看]
http://m.baichuan365.com/Article/20240130_industrialnews_1.html
《Cell》身體發炎,究竟是誰負責精準地招募中性粒細胞?
新的研究表明,細胞表面RNA是中性粒細胞募集到炎癥部位的關鍵。這些中性粒細胞細胞表面的“糖RNA”促進與內皮細胞的結合和跨內皮細胞的遷移。結合先前的研究表明,glycoRNAs可以在許多細胞類型中發現,glycoRNAs可能在多種細胞類型和多種生物環境中發揮重要功能。[查看]
http://m.baichuan365.com/Article/20240124_industrialnews_1.html
P<font color='red'>NAS</font>:脂肪酸調節脂質生物合成的新途徑
在最近的一項研究中,筑波大學的一組研究人員發現了一種新的SREBP-1c裂解酶,SREBP-1c是脂肪酸生物合成的關鍵角色。此外,該團隊首次揭示了肝臟中脂肪酸的生物合成過程是由飽和脂肪酸激活的,而由多不飽和脂肪酸抑制的[查看]
http://m.baichuan365.com/Article/pnaszfsdjzzswhcdxtj_1.html
P<font color='red'>NAS</font>:一種新的檢測方法有望早期發現帕金森病
布里格姆婦女醫院的研究人員,麻省總醫院布里格姆的創始成員,和哈佛大學Wyss生物啟發工程研究所開發了一種分子分析平臺,他們成功地應用于患者樣本,以檢測和量化單個synuclein原纖維,synuclein的致病聚集體是PD和其他神經退行性疾病的標志,被稱為synucleinopathies。他們的研究結果發表在《美國科學院院刊》上。[查看]
http://m.baichuan365.com/Article/pnasyzxdjcffywzqfxpj_1.html
《P<font color='red'>NAS</font>》合成酶來解開分子之謎
克薩斯大學達拉斯分校的一位生物工程師開發出了一種合成酶,可以控制信號蛋白Vg1的行為,Vg1在脊椎動物胚胎的肌肉、骨骼和血液的發育中起著關鍵作用。[查看]
http://m.baichuan365.com/Article/pnashcmljkfzzm_1.html
P<font color='red'>NAS</font>:活性酶的圖像揭示了耐抗生素細菌的秘密
先進的顯微鏡技術為科學家們提供了有價值的線索,讓他們知道如何對抗一種導致全球抗生素耐藥性細菌感染病例增加的核糖體修飾酶。[查看]
http://m.baichuan365.com/Article/pnashxmdtxjslnkssxjd_1.html
《P<font color='red'>NAS</font>》從過度反應蛋白合成到認知障礙,敲除1個基因即可
日本理研研究所的研究人員發現了蛋白質合成與神經發育障礙之間的聯系,發現蛋白質生產過程中過度活躍的質量控制過程會抑制神經生長和交流,導致認知功能障礙。這為治療這類疾病開辟了潛在的新途徑。[查看]
http://m.baichuan365.com/Article/20230727_1.html
P<font color='red'>NAS</font>新研究:致病菌利用腸道黏液層中的一種糖來感染腸道
發表在《美國國家科學院院刊》(PNAS)上的研究結果表明,腸道細菌感染和一系列與腸道細菌有關的慢性疾病,包括炎癥性腸病(IBD)、乳糜瀉、腸易激綜合征和短腸綜合征,都有可能成為治療目標。[查看]
http://m.baichuan365.com/Article/pnasSialicacid_1.html
P<font color='red'>NAS</font>:基于CRISPR/cas9的基因驅動可以抑制農業害蟲
北卡羅來納州立大學研究人員已經開發出一種基于CRISPR/Cas9的“歸巢基因驅動系統”,可以用來抑制斑翅果蠅 Drosophila suzukii 的數量。研究人員開發了雙CRISPR基因驅動系統,針對一種特定的斑翅果蠅基因,這種基因被稱為doublesex,對果蠅的性發育很重要。[查看]
http://m.baichuan365.com/Article/pnasjycrisprcas9djyq_1.html
IL-17蛋白對皮膚老化的關鍵作用
來自巴塞羅那生物醫學研究所(IRB Barcelona)與國家基因組分析中心(CNAG)合作的一組科學家發現,IL-17蛋白在皮膚老化中起著核心作用。這項研究由巴塞羅那IRB的Guiomar Solanas博士、Salvador Aznar Benitah博士和CNAG的Holger Heyn博士領導,強調了Il -17介導的衰老過程到炎癥狀態。[查看]
http://m.baichuan365.com/Article/il17dbdpflhdgjzy_1.html
P<font color='red'>NAS</font>意外發現線粒體的更多功能:細胞可塑性
長期以來,研究人員一直認為,一旦細胞開始分化,長成皮膚細胞、肝細胞或神經元,這條道路就無法改變。但在過去的二十年里,科學家們意識到這條途徑要復雜得多。現在,密歇根大學(University of Michigan)的一個研究小組以斑馬魚為模型,發現人體線粒體(細胞內為身體產生能量的細胞器)中的一個環可能允許細胞在分化的道路上后退。他們的研究結果發表在《美國國家科學院院刊》上。[查看]
http://m.baichuan365.com/Article/pnasywfxxltdgdgnxbks_1.html
《P<font color='red'>NAS</font>》對抗慢性炎癥和傳染病,如何調動我們的細胞的愈合能力
昆士蘭大學分子生物科學研究所的Kaustav Das Gupta教授和Matt Sweet博士發現,免疫細胞中從葡萄糖中提取的一種分子5-磷酸核酮糖具有阻止細菌生長和抑制炎癥反應的能力。這一發現代表了未來治療方法發展的關鍵一步,可以訓練免疫細胞。[查看]
http://m.baichuan365.com/Article/HDAC7switch_1.html
P<font color='red'>NAS</font>突破性新發現:幫助細菌在人類呼吸道定植的CPS特征
新加坡國立大學醫學院(NUS Medicine)的科學家們在一項突破性的發現中,發現了幫助細菌在人類呼吸道定植的CPS的特征。研究表明,CPS膠囊的結構及其連接和組合類型在允許細菌更好地附著在人類上呼吸道和下呼吸道內壁上并存活方面起著重要作用。[查看]
http://m.baichuan365.com/Article/pnastpxxfxbzxjzrlhxd_1.html
CAR-T療法創始人P<font color='red'>NAS</font>發文:實體腫瘤治療曙光出現?利用“組合拳”幫助T細胞
發表在《美國國家科學院院刊》(PNAS)上的研究結果表明,靶向控制炎癥相關基因功能的兩種調節因子,可使模型中的T細胞至少增加10倍,從而增強抗腫瘤免疫活性和持久性。[查看]
http://m.baichuan365.com/Article/cartlfcsrpnasfwstzlz_1.html
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Penicillinase Bulk Powder
Penicillinase Bulk Powder
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
Mab<CK-MM> Mix creatinine kinase isoenzyme MM
Mab Mix creatinine kinase isoenzyme MM
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.52)
Creatine Kinase-MM Monoclonal Antibody (14.52)