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類泛素化E3連接酶調(diào)節(jié)小鼠造血功能
近日,來自美國的科學家在國際學術期刊cell death & differentiation在線發(fā)表了一項最新研究進展,他們發(fā)現(xiàn)ufm1連接系統(tǒng)的E3連接酶RCAD/Ufl1對于調(diào)節(jié)造血干細胞功能及小鼠造血發(fā)育具有重要調(diào)控作用。 Ufm1(ubiquitin-fold modifier1)連接系統(tǒng)是一種新的類泛素修飾系統(tǒng),與其他的一些類泛素修飾系統(tǒng)具有類似的生化特征。Ufm1途徑通過特異性的 E1(uba5),E2(ufc1),E3三種酶催化介導對靶蛋白對修飾,但關于E3連接酶的研究一直較少。 之前有研究報道[查看]
http://m.baichuan365.com/Article/lfshe3ljmdjxszxgn_1.html
老年癡呆的早期生物標記物:嗅覺障礙
嗅球處神經(jīng)纖維纏結是阿爾茨海默?。?font color='red'>AD)的早期病理表現(xiàn)。為明確嗅覺障礙在預測未來認知功能下降與AD癡呆中的實用性,來自哥倫比亞大學的Devanand教授開展了一項前瞻性觀察研究,證實嗅覺損害不僅可預測“健康”人群的認知受損,還能早期預測輕度認知功能下降(MCI)發(fā)展為AD癡呆的可能性,該研究發(fā)表在近期的Neurology雜志。 該研究在紐約北麥哈頓的一個多民族社區(qū)人群中進行,共納入1037例認知功能正常的受試者。研究者采用賓夕法尼亞大學嗅覺鑒定試驗(UPSIT)對受試者進行嗅覺測試,UPS[查看]
http://m.baichuan365.com/Article/lncddzqswbjwxjza_1.html
生物醫(yī)藥大泡沫已吹起!
【新聞事件】:今天早晨百建艾迪宣布其阿爾茨海默(AD)藥物,淀粉狀蛋白抗體aducanumab(代號BIIB037)在一個一期臨床實驗中表現(xiàn)出色。根據(jù)不同測試方法,使用54周最高劑量aducanumab的病人比安慰劑組病人認知功能障礙惡化緩解70-80%,這遠高于專家估計的20-30%緩解。雖然55%的ApoE4基因攜帶者(高危人群)使用最高劑量aducanumab有腦腫脹副作用,但百建艾迪股票還是飆升8%。自去年12月百建艾迪宣布aducanumab的積極療效其市值已增加了350億美元。 【藥源解析】:前一段時[查看]
http://m.baichuan365.com/Article/swyydpmycq_1.html
《科學》雜志刊登麝香保心丸研究成果
傳統(tǒng)中藥登上世界舞臺 2015年1月16日,世界權威學術雜志之一——《科學》(Science)在其中醫(yī)藥??袑晗惚P耐璧难芯砍晒M行了專題報道[Science2015,347(6219sppl),S40,圖]。 《Science》雜志是美國科學促進會(American Association for the Advancement of Science,AAAS)出版的一份學術期刊,為全世界最權威的學術期刊之一,其2013年的影響因子已超過30?!禨cience》雜志具有新聞雜志和學[查看]
http://m.baichuan365.com/Article/kxzzkdsxbxwyjcg_1.html
首例老年癡呆癥,帕金森癥活體檢測技術
來自墨西哥圣路易斯波托西中央醫(yī)院的研究者們發(fā)現(xiàn)來自AD或PD的患者的活體皮膚樣本中的tau蛋白以及α-Syn蛋白的含量要顯著高于對照組。
[查看]
http://m.baichuan365.com/Article/sllncdzpjszhtjcjs_1.html
Glucomannan 葡甘聚糖 - Elicityl生物質(zhì)提取甘露聚糖產(chǎn)品(4)
[查看]
http://m.baichuan365.com/Article/elicityl_Glucomannan_1.html
Mannan 甘露聚糖 - Elicityl生物質(zhì)提取甘露聚糖產(chǎn)品(1)
甘露聚糖是由β(1-4)鏈接D-甘露吡喃糖殘基構成,在自然界蘊藏豐富,是從單子葉植物(如棕櫚科植物,例如象牙果(Phytelephas sp.)、海棗(Phoenix dactylifera))胚乳或部分隸屬松藻科(Codiaceae)和傘藻科(Dasycladaceae)的綠藻細胞壁中獲得的純的均一聚合物。[查看]
http://m.baichuan365.com/Article/elicityl_Mannan_1.html
價格戰(zhàn)烽煙再起,天價藥還能風光多久?
生物制藥公司艾伯維(Abb Vie)與快捷藥方公司(Express Scripts)近日達成了協(xié)議,決定將其售價83,319美元、用于丙肝治療的新藥ViekiraPak以非常優(yōu)惠的折扣出售(具體折扣沒有披露)。對于生物技術領域的投資者來說,這一消息無疑是一場災難。這意味著,吉利德制藥公司(Gilead Pharmaceuticals)在銷售其丙肝治療藥物Sovaldi(每療程售價84,000美元)和Harvoni(每療程售價95,000美元)時,不僅僅要與競爭對手拼療效(吉利德的兩種藥療效無疑更好),還要拼價格。華[查看]
http://m.baichuan365.com/Article/jgzfyzqtjyhnfgdj_1.html
老年癡呆癥研究(Alzheimer’s Disease)相關試劑盒 -- 疾病診斷及研究系列(3)
西寶生物提供日本W(wǎng)ako原裝進口老年癡呆癥研究相關(Alzheimer’s Disease)試劑盒,為研究AD疾病提供檢測依據(jù),貨期保證,質(zhì)量好!! 咨詢/訂購熱線:400-021-8158[查看]
http://m.baichuan365.com/Article/Alzheimers_disease_Kit_1.html
選擇性還原催化劑1 -Osmium-Activated Carbon Palladium Catalyst Series 1
在接觸性還原反應中,作為不均勻觸媒的鈀碳(Pd/C),在溫和、中性條件下,被用于各種官能基高效還原。不過,因為Pd/C具有強還原能力,要實現(xiàn)官能基選擇和位置選擇是很困難的。 本公司為了解決這些問題,現(xiàn)正銷售各種催化劑毒性不同的Pd固定化催化劑、鋨和活性碳的復合化催化劑。[查看]
http://m.baichuan365.com/Article/xzxhychj1osmiumactiv_1.html
選擇性還原催化劑2-Osmium-Activated Carbon Palladium Catalyst Series2
在接觸性還原反應中,作為不均勻觸媒的鈀碳(Pd/C),在溫和、中性條件下,被用于各種官能基高效還原。不過,因為Pd/C具有強還原能力,要實現(xiàn)官能基選擇和位置選擇是很困難的。[查看]
http://m.baichuan365.com/Article/xzxhychj2osmiumactiv_1.html
供應體外診斷試劑(IVD,Diagnostic Reagents )研發(fā)生產(chǎn)用的生物活性材料:動物疫病類的抗原(Ag)、抗體(Ab)、酶(Enzyme)等
  家畜和家禽的健康狀況對動物制品影響很大。在某些情況下通過測定動物血液中特定蛋白的水平可以監(jiān)測動物的健康狀況。西寶生物®(Seebio®),可以提供獸醫(yī) Veterinary的抗原(Ag)、抗體(Ab)、酶(Enzyme)等相關系類產(chǎn)品: 腺病毒   Adenovirus 酸性糖蛋白    Alpha 1-acid glycoprotein (AGP) alpha α1- 星狀病毒Ast[查看]
http://m.baichuan365.com/Article/Veterinary_1.html
熊去氧膽酸功能用輔酶--煙酰胺腺嘌呤雙核苷酸 N<font color='red'>AD</font>+ (53-84-9)
西寶生物長期穩(wěn)定現(xiàn)貨供應煙酰胺腺嘌呤雙核苷酸 NAD+ (53-58-9)產(chǎn)品,克到公斤級。NAD+是一種在所有活細胞中都可以發(fā)現(xiàn)的輔酶,是現(xiàn)代生物催化反應必不可少的輔酶之一。[查看]
http://m.baichuan365.com/Article/NADP_1.html
免疫磁性微球
表面結合有單克隆抗體的磁性微球稱為免疫磁性微球(Immunomagnetic Microspheres,IMMS),或稱免疫磁珠(Immunomagnetic Beads,IMB)。 由于它能特異性地與靶物質(zhì)結合并使之具有磁響應性,因此將免役磁性微球與含有靶物質(zhì)(欲分離的物質(zhì))的復雜混合物共同培養(yǎng)。則免疫性微球可以通過抗原抗體反應選擇性地與靶物質(zhì)結合,當此化合物通過一個磁場裝置時,與免疫磁性微球結合的靶物質(zhì)就會被磁場滯留,從而與其他復雜物質(zhì)分離開來。 應用:免疫磁性微球主要用于細胞分離等方面。將已包被了[查看]
http://m.baichuan365.com/Article/1412_1.html
線性-樹枝狀聚合物 Linear-Dendritic Hybrids
西寶生物提供樹枝狀多功能聚乙二醇(PEG)。 1、PEG 6k Core 2、PEG 20k Core 3、Tailor Made 貨號 品名 代數(shù) 末端官能團數(shù) [查看]
http://m.baichuan365.com/Article/1267_1.html
記錄總數(shù):713 | 頁數(shù):48  <...39404142434445464748  
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Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 1,000ug/mL in 5% HCl
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 5% HCl (v/v) 1000ug/mL
Palladium 10,000ug/mL in 5% HCl
Palladium 10,000ug/mL in 5% HCl
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2-5% HNO3 (v/v) 100ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HNO3 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2% HCl 1,000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 1000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 2-5% HNO3 (v/v) 10000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HNO3 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Vanadium 15% HCl 10,000ug/mL
Silver Vanadate
Silver Vanadate
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Cadmium in 0.005% HNO3 1000ppm
Lead in 0.005% HNO31000ppm
Lead in 0.005% HNO31000ppm
Cadmium inin 0.005% HNO3 100ppm
Cadmium inin 0.005% HNO3 100ppm
Lead in 0.005% HNO3 1000ppm
Lead in 0.005% HNO3 1000ppm
17β-Estradiol
17β-Estradiol
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
Lead-Free Solder Chip(Sn96.5 Ag3 Cu0.5)-Pb High Concentration
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
n-Octadecyl 3-(3',5'-Di-t-butyl-4'-hydroxyphenyl)propionate Standard
Lead Acetate Solution (CH COO) Pb, 10%
Lead Acetate Solution (CH COO) Pb, 10%
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Advanced ERK phospho-T202 /Y204 kit - 1 x 96 tests
Di(adenosine-5'-)penta-phosphate,trilithium salt
Di(adenosine-5'-)penta-phosphate,trilithium salt
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
Zwittergent 3-14,zwitterionic detergent, powder, N-Tetradecyl-N,N-dimethyl-3-ammonio-1-propane-sulfonate
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
氧化型輔酶I|煙酰胺腺嘌呤二核苷酸|53-84-9| β-NAD
Glucose dehydrogenase (NAD(P)-dependent)
Glucose dehydrogenase (NAD(P)-dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase(NADP dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NAD dependent)
Glutamate dehydrogenase (NADP dependent)
Glutamate dehydrogenase (NADP dependent)
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
ADP-dependent Hexokinase
Diaphorase (NADH)
Diaphorase (NADH)
Diaphorase (NADPH)
Diaphorase (NADPH)
NAD Synthetase
NAD Synthetase
Adenosine Deaminase,from calf intestine, suspension
Adenosine Deaminase,from calf intestine, suspension
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from E.coli overproducer, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, chemically modified, lyophilizate
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
Glutamate Dehydrogenase (NAD(P)),from beef liver, solution
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade I
D-乳酸脫氫酶(D-LDH), Grade II
D-乳酸脫氫酶(D-LDH), Grade II
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
NAD(P)H Dehydrogenase (quinone) (Diaphorase),from pig heart, suspension
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase MTF C/T, GMP Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Liberase T-Flex, Research Grade,sterile filtered, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Asp-N, Sequencing Grade,from a mutant of Pseudomonas fragi, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Glu-C, Sequencing Grade,from Staphylococcus aureus V8, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, lyophilizate
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Endoproteinase Lys-C, Sequencing Grade,from Lysobacter enzymogenes, solution
Glucose Dehydrogenase (NAD Dependent)
Glucose Dehydrogenase (NAD Dependent)
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade I,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Glucose Oxidase (GOD), Grade II,from Aspergillus niger overproducer, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
Peroxidase (POD), Grade II,from horse radish, lyophilizate
DADK嗪草酮標準品
DADK嗪草酮標準品
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
1-cis-3-Chloroallyl-3,5,7-triaza-1-azonia-adamantane chloride
Oxadiargyl
Oxadiargyl
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
USP Solution Lead Acetate TS Conforms to USP 34
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate cotton
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopoeia Reagent Lead acetate paper
European Pharmacopeoia Lead Acetate Solution
European Pharmacopeoia Lead Acetate Solution
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent Molybdovanadic reagent
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent 0.1M Lead Nitrate
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Reagent Concentrated to make Cadmium Standard sol. (0.1% Cd)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Lead Solution (0.1% Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
European Pharmacopoeia Reagent Concentrate to make Lead solution (100ppm Pb)
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),100ug/mL (as pyrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
EDDP perchlorate (Methadone metabolite),1.0mg/mL (as pyrrolinium) 于甲醇
Loratadine impurity F
Loratadine impurity F
氧化鋁 (Reduction Grade) 標準物質(zhì)
氧化鋁 (Reduction Grade) 標準物質(zhì)
MAB<HCG>M-INN22-IgG Human chorionic gonadotropin b-chain
MABM-INN22-IgG Human chorionic gonadotropin b-chain